Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.45 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659999 | 0.84 | MMP12 (0.46) | TDP1MAOBBAZ2BBAZ2AKDM4E | |
| SCHEMBL1662612 | 0.82 | MEN1 (0.51) | BAZ2BBAZ2AKDM4EALDH1A1KMT2A | |
| SCHEMBL388580 | 0.78 | BAZ2B (0.70) | L3MBTL1MAOAMAOBBAZ2BBAZ2A | |
| SCHEMBL29071873 | 0.75 | TDP1 (0.62) | TDP1L3MBTL1MAOAMAOBKDM4E | |
| SCHEMBL1658699 | 0.75 | L3MBTL1 (0.53) | TDP1L3MBTL1BAZ2BBAZ2AKDM4E | |
| SCHEMBL1660685 | 0.74 | TSHR (0.53) | TDP1L3MBTL1BAZ2BBAZ2AKDM4E | |
| SCHEMBL19024920 | 0.74 | CA12 (0.59) | TDP1L3MBTL1MAOAMAOBKDM4E | |
| SCHEMBL26235469 | 0.73 | BRD4 (0.49) | TDP1L3MBTL1BAZ2BBAZ2AKDM4E | |
| SCHEMBL1642066 | 0.72 | MAPK10 (0.46) | L3MBTL1MAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL5182727 | 0.71 | TP53 (0.47) | TDP1L3MBTL1MAOAMAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306828-A1 | PROLYL HYDROXYLASE INHIBITORS | Glaxosmithkline LLC (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009158315-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |