Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 14/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660016 | 0.82 | TDP1 (0.47) | MEN1KMT2ABAZ2BBAZ2ANPC1 | |
| SCHEMBL1658699 | 0.75 | L3MBTL1 (0.53) | MEN1KMT2ABAZ2BBAZ2ANPC1 | |
| SCHEMBL1642299 | 0.75 | MAPT (0.47) | MEN1KMT2AMAP2K1MAP2K2KDM4E | |
| SCHEMBL388580 | 0.73 | BAZ2B (0.70) | MEN1KMT2AMAP2K1MAP2K2BAZ2B | |
| SCHEMBL1659999 | 0.72 | MMP12 (0.46) | KMT2ABAZ2BBAZ2ANPC1RAB9A | |
| SCHEMBL13034145 | 0.72 | MEN1 (0.53) | MEN1KMT2AALDH1A1 | |
| SCHEMBL5623781 | 0.71 | MAP2K1 (0.77) | MAP2K1MAP2K2 | |
| SCHEMBL1660685 | 0.70 | TSHR (0.53) | MEN1KMT2AMAP2K1MAP2K2BAZ2B | |
| SCHEMBL26235469 | 0.68 | BRD4 (0.49) | MEN1KMT2ABAZ2BBAZ2AKDM4E | |
| SCHEMBL13811548 | 0.68 | MEN1 (0.47) | MEN1KMT2ANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306828-A1 | PROLYL HYDROXYLASE INHIBITORS | Glaxosmithkline LLC (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009158315-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |