Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.50 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.50 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388580 | 0.83 | BAZ2B (0.70) | TSHRBAZ2BBAZ2APOLBMAPT | |
| SCHEMBL26235469 | 0.81 | BRD4 (0.49) | TSHRBAZ2BBAZ2APOLBL3MBTL1 | |
| SCHEMBL17156651 | 0.76 | BAZ2B (0.47) | TSHRBAZ2BBAZ2APOLBMAPT | |
| SCHEMBL1660016 | 0.74 | TDP1 (0.47) | BAZ2BBAZ2AMAPTL3MBTL1KDM4E | |
| SCHEMBL1660138 | 0.74 | BAZ2B (0.45) | BAZ2BBAZ2AMAP2K1KMT2AMEN1 | |
| SCHEMBL1640291 | 0.73 | CA12 (0.41) | TSHRPOLBMAPTL3MBTL1MAP2K2 | |
| SCHEMBL1658699 | 0.72 | L3MBTL1 (0.53) | BAZ2BBAZ2AMAPTL3MBTL1KDM4E | |
| SCHEMBL21318155 | 0.72 | SERPINE1 (0.83) | TSHRSERPINE1POLBMAPTL3MBTL1 | |
| SCHEMBL1659999 | 0.71 | MMP12 (0.46) | TSHRBAZ2BBAZ2AMAPTKDM4E | |
| SCHEMBL12767250 | 0.71 | MPO (0.44) | BAZ2BBAZ2AMAP2K2MAP2K1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306828-A1 | PROLYL HYDROXYLASE INHIBITORS | Glaxosmithkline LLC (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009158315-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |