Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | CYP2A6 | P11509 | 8/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.58 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.58 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | HPGDS | O60760 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17101469 | 0.98 | KDM4E (0.57) | KDM4ESMN1; SMN2CYP2A6CYP3A4CYP2E1 | |
| SCHEMBL12279413 | 0.81 | HPGDS (0.71) | KDM4ESMN1; SMN2CYP2A6CYP3A4CYP2E1 | |
| SCHEMBL5154428 | 0.80 | ALDH1A1 (0.49) | KDM4ESMN1; SMN2HPGDSCYP1A2ALDH1A1 | |
| SCHEMBL2684464 | 0.79 | KDM4E (0.52) | KDM4ESMN1; SMN2CYP2A6CYP3A4CYP2E1 | |
| SCHEMBL8031390 | 0.78 | HPGDS (0.54) | KDM4ESMN1; SMN2CYP2A6CYP3A4CYP2E1 | |
| SCHEMBL2820252 | 0.78 | HPGDS (0.54) | KDM4ESMN1; SMN2CYP2A6CYP3A4CYP2E1 | |
| SCHEMBL17803411 | 0.75 | HPGDS (0.68) | KDM4ESMN1; SMN2CYP2A6CYP3A4CYP2E1 | |
| SCHEMBL16088995 | 0.75 | HPGDS (0.51) | KDM4ESMN1; SMN2CYP2A6CYP3A4CYP2E1 | |
| SCHEMBL5392323 | 0.75 | CYP3A4 (0.56) | KDM4ESMN1; SMN2CYP2A6CYP3A4CYP2C9 | |
| SCHEMBL29548990 | 0.75 | CYP3A4 (0.56) | KDM4ESMN1; SMN2CYP2A6CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109415358-B | 6-aminopyridin-3-ylthiazoles as ROR gamma t modulators | 詹森药业有限公司 | 2022-04-05 | — | — | CN | disclosed |
| CN-108812681-B | Pesticidal compositions and methods related thereto | 美国陶氏益农公司 | 2021-02-26 | — | — | CN | disclosed |
| US-RE48057-E1 | Pesticidal compositions and related methods | DOW AGROSCIENCES LLC (US) | 2020-06-23 | — | — | US | disclosed |
| EP-3062619-B1 | PESTICIDAL COMPOSITIONS AND RELATED METHODS | DOW AGROSCIENCES LLC (US) | 2019-07-24 | — | — | EP | disclosed |
| CN-106458983-A | Novel compound | 拜耳制药股份公司 | 2017-02-22 | — | — | CN | disclosed |
| EP-2855468-B1 | PROCESSES TO PRODUCE CERTAIN 2-(PYRIDINE-3-YL)THIAZOLES | DOW AGROSCIENCES LLC (US) | 2016-11-02 | — | — | EP | disclosed |
| EP-2855468-B1 | PROCESSES TO PRODUCE CERTAIN 2-(PYRIDINE-3-YL)THIAZOLES | DOW AGROSCIENCES LLC (US) | 2016-11-02 | — | — | EP | disclosed |
| EP-3062619-A1 | PESTICIDAL COMPOSITIONS AND RELATED METHODS | Dow AgroSciences LLC (US) | 2016-09-07 | — | — | EP | disclosed |
| CN-105682462-A | Pesticidal compositions and methods related thereto | 美国陶氏益农公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-105658059-A | Pesticidal compositions and related methods | 美国陶氏益农公司 | 2016-06-08 | — | — | CN | disclosed |
| EP-2604267-B1 | Process for the preparation of thiazole derivatives | DOW AGROSCIENCES LLC (US) | 2016-02-03 | — | — | EP | disclosed |
| US-9137998-B2 | Pesticidal compositions and related methods | DOW AGROSCIENCES LLC (US) | 2015-09-22 | — | — | US | disclosed |
| EP-2604268-B1 | Process for the preparation of thiazole derivatives | DOW AGROSCIENCES LLC (US) | 2015-09-16 | — | — | EP | disclosed |
| CN-104603131-A | Process for preparing certain 2- (pyridin-3-yl) thiazoles | DOW AGROSCIENCES LLC | 2015-05-06 | — | — | CN | disclosed |
| WO-2015061151-A1 | PESTICIDAL COMPOSITIONS AND RELATED METHODS | DOW AGROSCIENCES LLC (US) | 2015-04-30 | — | — | WO | disclosed |
| US-20150111730-A1 | PESTICIDAL COMPOSITIONS AND RELATED METHODS | CORTEVA AGRISCIENCE LLC | 2015-04-23 | — | — | US | disclosed |
| US-8993769-B2 | Processes to produce certain 2-(pyridine-3-yl)thiazoles | DOW AGROSCIENCES, LLC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-8993769-B2 | Processes to produce certain 2-(pyridine-3-yl)thiazoles | DOW AGROSCIENCES, LLC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-8993769-B2 | Processes to produce certain 2-(pyridine-3-yl)thiazoles | DOW AGROSCIENCES, LLC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20130324735-A1 | PROCESSES TO PRODUCE CERTAIN 2-(PYRIDINE-3-YL)THIAZOLES | CORTEVA AGRISCIENCE LLC | 2013-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130324735-A1 | PROCESSES TO PRODUCE CERTAIN 2-(PYRIDINE-3-YL)THIAZOLES | PTMS, TH, TPP2 | KDM4E 1681/4885SMN1; SMN2 3827/4885CYP2A6 253/4885 |
| US-20150111730-A1 | PESTICIDAL COMPOSITIONS AND RELATED METHODS | ACHE, RDX, CHRM2 | KDM4E 1162/4885SMN1; SMN2 2418/4885CYP2A6 2776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.