Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15520701 | 0.87 | L3MBTL1 (0.50) | NR3C2MAOBPARP10L3MBTL1SLC1A1 | |
| SCHEMBL14699373 | 0.84 | ADORA2A (0.47) | L3MBTL1PARP1 | |
| SCHEMBL16612943 | 0.82 | SIGMAR1 (0.47) | NR3C2TAAR1MAOBDAOPARP1 | |
| SCHEMBL16612828 | 0.80 | SIRT2 (0.39) | MAOBPARP10PARP1 | |
| SCHEMBL15520668 | 0.76 | HDAC1 (0.34) | L3MBTL1PARP1 | |
| SCHEMBL16612788 | 0.74 | MPO (0.56) | HTR2A | |
| SCHEMBL15520768 | 0.73 | LMNA (0.40) | MAOBPARP10MAPT | |
| SCHEMBL14699416 | 0.73 | HTT (0.43) | L3MBTL1 | |
| SCHEMBL1718132 | 0.73 | PARP1 (0.48) | L3MBTL1PARP1 | |
| SCHEMBL14699254 | 0.72 | HDAC1 (0.44) | PARP10PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | disclosed |