Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 8/20 | 0.35 |
| ▸ | JAK1 | P23458 | 7/20 | 0.35 |
| ▸ | TYK2 | P29597 | 6/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612841 | 0.86 | MAPT (0.40) | HCRTR2JAK2HCAR3 | |
| SCHEMBL16612665 | 0.83 | HCRTR2 (0.39) | HCRTR2JAK2JAK1 | |
| SCHEMBL16613011 | 0.80 | HCRTR2 (0.36) | HCRTR2GRM5 | |
| SCHEMBL16612775 | 0.76 | MAOB (0.41) | — | |
| SCHEMBL16612726 | 0.75 | ALDH1A1 (0.40) | HCRTR2 | |
| SCHEMBL16612738 | 0.75 | HCRTR2 (0.36) | HCRTR2TYK2 | |
| SCHEMBL16612690 | 0.75 | HCRTR2 (0.35) | HCRTR2 | |
| SCHEMBL16612866 | 0.73 | HCRTR2 (0.41) | HCRTR2 | |
| SCHEMBL16612683 | 0.72 | FDPS (0.45) | HCRTR2 | |
| SCHEMBL15520768 | 0.71 | LMNA (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |