Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.39 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.39 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PLK1 | P53350 | 4/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16613026 | 0.85 | HDAC6 (0.40) | MTNR1AMTNR1BHCRTR2PLK1 | |
| SCHEMBL16612854 | 0.82 | MTNR1A (0.52) | MTNR1AMTNR1BHCRTR1HCRTR2HTT | |
| SCHEMBL16612739 | 0.81 | TDP1 (0.54) | HTTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL16612868 | 0.81 | MTNR1A (0.49) | MTNR1AMTNR1BHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL16612936 | 0.76 | MTNR1A (0.50) | MTNR1AMTNR1BHCRTR2 | |
| SCHEMBL16612997 | 0.76 | HCRTR2 (0.42) | MTNR1AMTNR1BHCRTR1HCRTR2HTT | |
| SCHEMBL27038883 | 0.76 | MTNR1A (0.65) | MTNR1AMTNR1BHCRTR1HCRTR2CDYL2 | |
| SCHEMBL16612857 | 0.75 | MTNR1A (0.44) | MTNR1AMTNR1BALDH1A1MAPK1MAPK10 | |
| SCHEMBL16612770 | 0.74 | ADRB2 (0.44) | MTNR1AMTNR1BHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL12479232 | 0.73 | MTNR1A (0.66) | MTNR1AMTNR1BCDYL2CDYLCDY1; CDY1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |