Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ADA | P00813 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612936 | 0.94 | MTNR1A (0.50) | MTNR1AMTNR1BHTR2AHTR2CMCL1 | |
| SCHEMBL16612868 | 0.93 | MTNR1A (0.49) | MTNR1AMTNR1BHTR2AHTR2CHCRTR1 | |
| SCHEMBL16612831 | 0.86 | HCRTR2 (0.42) | MTNR1AMTNR1BHCRTR1HCRTR2HDAC8 | |
| SCHEMBL16612876 | 0.84 | HTR2C (0.41) | MTNR1AMTNR1BHTR2AHTR2CHTR7 | |
| SCHEMBL16612628 | 0.83 | HCRTR2 (0.43) | MTNR1AMTNR1BMCL1HCRTR1HCRTR2 | |
| SCHEMBL16612997 | 0.83 | HCRTR2 (0.42) | MTNR1AMTNR1BMCL1HCRTR1HCRTR2 | |
| SCHEMBL16612954 | 0.83 | LMNA (0.53) | MTNR1AMTNR1BHTR2AHTR2CLMNA | |
| SCHEMBL16612656 | 0.82 | HCRTR2 (0.42) | MTNR1AMTNR1BHCRTR1HCRTR2HDAC8 | |
| SCHEMBL16612856 | 0.82 | MTNR1A (0.54) | MTNR1AMTNR1BHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL16613000 | 0.81 | HTR2A (0.42) | MTNR1AMTNR1BHTR2AHTR2CMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |