Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 8/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | ADA | P00813 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612854 | 0.94 | MTNR1A (0.52) | MTNR1AMTNR1BMCL1HTR2AHTR2C | |
| SCHEMBL16612868 | 0.86 | MTNR1A (0.49) | MTNR1AMTNR1BHTR2AHTR2CHCRTR2 | |
| SCHEMBL16612920 | 0.84 | CDK4 (0.52) | MTNR1AMTNR1B | |
| SCHEMBL16612831 | 0.80 | HCRTR2 (0.42) | MTNR1AMTNR1BHCRTR2 | |
| SCHEMBL16612997 | 0.78 | HCRTR2 (0.42) | MTNR1AMTNR1BMCL1HCRTR2 | |
| SCHEMBL16612628 | 0.78 | HCRTR2 (0.43) | MTNR1AMTNR1BMCL1HCRTR2 | |
| SCHEMBL16612876 | 0.78 | HTR2C (0.41) | MTNR1AMTNR1BHTR2AHTR2CHCRTR2 | |
| SCHEMBL16612954 | 0.77 | LMNA (0.53) | MTNR1AMTNR1BHTR2AHTR2C | |
| SCHEMBL16612656 | 0.77 | HCRTR2 (0.42) | MTNR1AMTNR1BHCRTR2 | |
| SCHEMBL16612856 | 0.76 | MTNR1A (0.54) | MTNR1AMTNR1BHCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |