Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TRPM5 | Q9NZQ8 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612854 | 0.83 | MTNR1A (0.52) | HCRTR2HCRTR1NPC1RAB9AALDH1A1 | |
| SCHEMBL16612868 | 0.82 | MTNR1A (0.49) | HCRTR2HCRTR1NPC1RAB9AALDH1A1 | |
| SCHEMBL16612831 | 0.82 | HCRTR2 (0.42) | HCRTR2HCRTR1MTNR1AMTNR1BTSHR | |
| SCHEMBL16613148 | 0.81 | HCRTR2 (0.42) | HCRTR2MTNR1AMTNR1B | |
| SCHEMBL16612656 | 0.79 | HCRTR2 (0.42) | HCRTR2HCRTR1MTNR1AMTNR1BTSHR | |
| SCHEMBL16612960 | 0.78 | HCRTR2 (0.41) | HCRTR2TRPM5 | |
| SCHEMBL16612936 | 0.78 | MTNR1A (0.50) | HCRTR2MTNR1AMTNR1BMCL1 | |
| SCHEMBL16612856 | 0.76 | MTNR1A (0.54) | HCRTR2HCRTR1ALDH1A1HPGDMTNR1A | |
| SCHEMBL16612628 | 0.76 | HCRTR2 (0.43) | HCRTR2HCRTR1MTNR1AMTNR1BMCL1 | |
| SCHEMBL16613000 | 0.75 | HTR2A (0.42) | HCRTR2HCRTR1LMNAMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |