Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ADA | P00813 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612854 | 0.93 | MTNR1A (0.52) | MTNR1AMTNR1BHTR2CHDAC8HDAC6 | |
| SCHEMBL16612831 | 0.87 | HCRTR2 (0.42) | MTNR1AMTNR1BHDAC8HDAC6HDAC3 | |
| SCHEMBL16613000 | 0.87 | HTR2A (0.42) | MTNR1AMTNR1BHTR2CHDAC8HDAC6 | |
| SCHEMBL16612936 | 0.86 | MTNR1A (0.50) | MTNR1AMTNR1BHTR2CHCRTR2HTR2A | |
| SCHEMBL12480072 | 0.84 | HTR2A (0.41) | HTR2CHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL16612982 | 0.84 | HCRTR2 (0.44) | MTNR1AMTNR1BHCRTR1HCRTR2 | |
| SCHEMBL16612656 | 0.83 | HCRTR2 (0.42) | MTNR1AMTNR1BHDAC8HDAC6HDAC3 | |
| SCHEMBL16612628 | 0.82 | HCRTR2 (0.43) | MTNR1AMTNR1BHCRTR1HCRTR2 | |
| SCHEMBL16612997 | 0.82 | HCRTR2 (0.42) | MTNR1AMTNR1BHCRTR1HCRTR2NPC1 | |
| SCHEMBL16612954 | 0.82 | LMNA (0.53) | MTNR1AMTNR1BHTR2CHTR2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | disclosed |