SCHEMBL16613460

SCHEMBL16613460

c1ccc(-c2nc(-n3c4ccccc4c4ccccc43)nc3sccc23)nc1

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KRAS P01116 1/20 0.45
ADORA1 P30542 5/20 0.41
ADORA2A P29274 3/20 0.39
MCL1 Q07820 6/20 0.38
VCP P55072 1/20 0.36
LRRK2 Q5S007 1/20 0.35
NPY5R Q15761 1/20 0.34
TGFBR1 P36897 2/20 0.34
KDM4E B2RXH2 1/20 0.33
NPC1 O15118 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16613703 0.89 KRAS (0.39) KRASADORA1ADORA2AMCL1VCP
SCHEMBL16613720 0.87 NPY5R (0.40) KRASADORA1ADORA2AMCL1VCP
SCHEMBL16613458 0.82 MCL1 (0.35) KRASADORA1ADORA2AMCL1VCP
SCHEMBL16613484 0.81 ADORA2A (0.42) ADORA1ADORA2AVCPKDM4E
SCHEMBL16613739 0.81 ADORA1 (0.55) ADORA1ADORA2AMCL1KDM4ENPC1
SCHEMBL12014847 0.80 MCL1 (0.47) MCL1KDM4ENPC1
SCHEMBL16613485 0.79 DHODH (0.41) ADORA1ADORA2AVCPKDM4E
SCHEMBL16613530 0.78 VCP (0.37) ADORA2AVCPKDM4E
SCHEMBL16613531 0.77 ADORA2A (0.39) ADORA2AVCPKDM4E
SCHEMBL16613533 0.77 DHODH (0.40) ADORA2AVCPKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015047058-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME 주식회사 두산 2015-04-02 WO disclosed