Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SDCBP | O00560 | 1/20 | 0.44 |
| ▸ | SDC2 | P34741 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HPN | P05981 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15322811 | 0.86 | NAMPT (0.50) | NAMPTL3MBTL1HDAC1HDAC6GAA | |
| SCHEMBL25440112 | 0.84 | NAMPT (0.51) | NAMPTL3MBTL1HDAC1HDAC6GAA | |
| SCHEMBL25440138 | 0.83 | NAMPT (0.47) | NAMPTL3MBTL1HDAC1HDAC6GAA | |
| SCHEMBL26085366 | 0.83 | CA1 (0.52) | NAMPTL3MBTL1HDAC1SDCBPSDC2 | |
| SCHEMBL30262636 | 0.83 | S1PR1 (0.41) | NAMPTHDAC1HDAC6GAAMAPT | |
| SCHEMBL3180689 | 0.82 | L3MBTL1 (0.61) | NAMPTL3MBTL1HDAC1HDAC6GAA | |
| SCHEMBL26054956 | 0.82 | NAMPT (0.47) | NAMPTL3MBTL1HDAC1HDAC6GAA | |
| SCHEMBL25367309 | 0.82 | NAMPT (0.47) | NAMPTL3MBTL1HDAC1HDAC6GAA | |
| SCHEMBL18237012 | 0.82 | CA1 (0.51) | NAMPTHDAC1GAASDCBPSDC2 | |
| SCHEMBL29383217 | 0.82 | CA1 (0.51) | NAMPTHDAC1GAASDCBPSDC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4199970-B1 | EXTRACORPOREAL CLEARING TRAPS BASED ON INVERSE ELECTRON DEMAND DIELS-ALDER CYCLOADDITION FOR (PRE)-TARGETED THERAPY AND DIAGNOSTICS | RIGSHOSPITALET (DK) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024210956-A1 | BIOGEL, COMPOSITIONS AND METHODS OF USE THE SAME | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2024-10-10 | — | — | WO | disclosed |
| US-20230310643-A1 | EXTRACORPOREAL CLEARING TRAPS BASED ON INVERSE ELECTRON DEMAND DIELS-ALDER CYCLOADDITION FOR (PRE)-TARGETED THERAPY AND DIAGNOSTICS | RIGSHOSPITALET (DK) | 2023-10-05 | — | — | US | disclosed |
| US-20230310643-A1 | EXTRACORPOREAL CLEARING TRAPS BASED ON INVERSE ELECTRON DEMAND DIELS-ALDER CYCLOADDITION FOR (PRE)-TARGETED THERAPY AND DIAGNOSTICS | RIGSHOSPITALET (DK) | 2023-10-05 | — | — | US | disclosed |
| US-20230310643-A1 | EXTRACORPOREAL CLEARING TRAPS BASED ON INVERSE ELECTRON DEMAND DIELS-ALDER CYCLOADDITION FOR (PRE)-TARGETED THERAPY AND DIAGNOSTICS | RIGSHOSPITALET (DK) | 2023-10-05 | — | — | US | disclosed |
| US-11767302-B2 | Reagents and methods for tetrazine synthesis | UNIVERSITY OF DELAWARE (US) | 2023-09-26 | — | — | US | disclosed |
| US-11767302-B2 | Reagents and methods for tetrazine synthesis | UNIVERSITY OF DELAWARE (US) | 2023-09-26 | — | — | US | disclosed |
| US-11767302-B2 | Reagents and methods for tetrazine synthesis | UNIVERSITY OF DELAWARE (US) | 2023-09-26 | — | — | US | disclosed |
| EP-4199970-A1 | EXTRACORPOREAL CLEARING TRAPS BASED ON INVERSE ELECTRON DEMAND DIELS-ALDER CYCLOADDITION FOR (PRE)-TARGETED THERAPY AND DIAGNOSTICS | Rigshospitalet (DK) | 2023-06-28 | — | — | EP | disclosed |
| US-20220106278-A1 | REAGENTS AND METHODS FOR TETRAZINE SYNTHESIS | UNIVERSITY OF DELAWARE (US) | 2022-04-07 | — | — | US | disclosed |
| WO-2022038183-A1 | EXTRACORPOREAL CLEARING TRAPS BASED ON INVERSE ELECTRON DEMAND DIELS-ALDER CYCLOADDITION FOR (PRE)-TARGETED THERAPY AND DIAGNOSTICS | RIGSHOSPITALET (DK) | 2022-02-24 | — | — | WO | disclosed |
| WO-2022038183-A1 | EXTRACORPOREAL CLEARING TRAPS BASED ON INVERSE ELECTRON DEMAND DIELS-ALDER CYCLOADDITION FOR (PRE)-TARGETED THERAPY AND DIAGNOSTICS | RIGSHOSPITALET (DK) | 2022-02-24 | — | — | WO | disclosed |
| EP-3539955-B1 | PROCESS FOR THE PREPARATION OF TETRAZINES | CENTRE NAT RECH SCIENT (FR) | 2021-07-28 | — | — | EP | disclosed |
| EP-3539955-A1 | METHOD FOR PREPARING TETRAZINES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2019-09-18 | — | — | EP | disclosed |
| US-9533957-B2 | Tetrazines and method of synthezising the same | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-01-03 | — | — | US | disclosed |
| US-20150099277-A1 | NOVEL TETRAZINES AND METHOD OF SYNTHEZISING THE SAME | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-04-09 | — | — | US | disclosed |
| US-20150099277-A1 | NOVEL TETRAZINES AND METHOD OF SYNTHEZISING THE SAME | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11767302-B2 | Reagents and methods for tetrazine synthesis | TST, CYP4F8, CYP4Z1 | NAMPT 1678/4885L3MBTL1 4082/4885HDAC1 1927/4885 |
| US-20150099277-A1 | NOVEL TETRAZINES AND METHOD OF SYNTHEZISING THE SAME | NBAS, NAA15, TALDO1 | NAMPT 2582/4885L3MBTL1 4096/4885HDAC1 1064/4885 |
| US-20220106278-A1 | REAGENTS AND METHODS FOR TETRAZINE SYNTHESIS | TST, CYP4F8, CYP4Z1 | NAMPT 1678/4885L3MBTL1 4082/4885HDAC1 1927/4885 |
| US-20230310643-A1 | EXTRACORPOREAL CLEARING TRAPS BASED ON INVERSE ELECTRON DEMAND DIELS-ALDER CYCLOADDITION FOR (PRE)-TARGETED THERAPY AND DIAGNOSTICS | ECE1, ELANE, EDNRA | NAMPT 1438/4885L3MBTL1 2475/4885HDAC1 2211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.