Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.58 |
| ▸ | CTSS | P25774 | 2/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16629561 | 0.86 | KMO (0.58) | KMOCTSSSYKKDM4EALDH1A1 | |
| SCHEMBL18014694 | 0.83 | KMO (0.55) | KMOCTSSSYKKDM4EALDH1A1 | |
| SCHEMBL893426 | 0.82 | TRPV3 (0.54) | IRAK4KDM1ACCNT1CCNA2CDK2 | |
| SCHEMBL2788482 | 0.81 | CCNT1 (0.63) | KMOCTSSKDM4EALDH1A1KDM1A | |
| SCHEMBL11469890 | 0.78 | KMO (0.62) | KMOCTSSKDM4EALDH1A1KDM1A | |
| SCHEMBL13273287 | 0.78 | KMO (0.62) | KMOCTSSKDM4EALDH1A1KDM1A | |
| SCHEMBL2302878 | 0.78 | CTSS (0.56) | KMOCTSSSYKKDM4EALDH1A1 | |
| SCHEMBL11468072 | 0.77 | KMO (0.58) | KMOCTSSKDM4EALDH1A1KDM1A | |
| SCHEMBL1514690 | 0.76 | HSP90AA1 (0.58) | IRAK4KDM4ENPC1RAB9AADORA2A | |
| SCHEMBL11467792 | 0.74 | LMNA (0.58) | KMOCTSSKDM4EALDH1A1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052495-B1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2019-06-26 | — | — | EP | disclosed |
| EP-3052495-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | Pfizer Inc. (US) | 2016-08-10 | — | — | EP | disclosed |
| WO-2015049616-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2015-04-09 | — | — | WO | disclosed |