Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Adamantane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | DAO | P14920 | 1/20 | 0.70 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.70 |
| ▸ | CES2 | O00748 | 3/20 | 0.58 |
| ▸ | CES1 | P23141 | 3/20 | 0.58 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adamantane SCHEMBL1653880 | 1.00 | TSHR (0.70) | TSHRDAONAPRTCES2CES1 | |
| Adamantane SCHEMBL163246 | 1.00 | TSHR (0.70) | TSHRDAONAPRTCES2CES1 | |
| Adamantane SCHEMBL11575814 | 1.00 | TSHR (0.70) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL28043411 | 0.91 | TSHR (0.64) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL2710114 | 0.86 | TSHR (0.52) | TSHRDAONAPRTCES2CES1 | |
| Benzophenone SCHEMBL29110866 | 0.85 | ALDH1A1 (0.70) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL975929 | 0.84 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL149318 | 0.84 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL407365 | 0.84 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL137419 | 0.84 | TSHR (1.00) | TSHRDAONAPRTCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 302 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2739169-B1 | POROUS CATALYTIC MATRICES FOR ELIMINATION OF TOXICANTS FOUND IN TOBACCO COMBUSTION PRODUCTS | MASSACHUSETTS INST TECHNOLOGY (US) | 2019-06-12 | — | — | EP | claimed |
| US-20140311507-A1 | Porous Catalytic Matrices for Elimination of Toxicants Found in Tobacco Combustion Products | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-10-23 | — | — | US | claimed |
| EP-2739169-A2 | POROUS CATALYTIC MATRICES FOR ELIMINATION OF TOXICANTS FOUND IN TOBACCO COMBUSTION PRODUCTS | Massachusetts Institute Of Technology (US) | 2014-06-11 | — | — | EP | claimed |
| WO-2013019865-A2 | POROUS CATALYTIC MATRICES FOR ELIMINATION OF TOXICANTS FOUND IN TOBACCO COMBUSTION PRODUCTS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-02-07 | — | — | WO | claimed |
| US-12630567-B2 | High yield synthesis of metal-organic frameworks | ExxonMobil Technology and Engineering Company (US) | 2026-05-19 | — | — | US | disclosed |
| US-20250276300-A1 | REDUCTION OF MONOMERIC ISOCYANATES BY POROUS MATERIAL | BASF SE (DE) | 2025-09-04 | — | — | US | disclosed |
| EP-4291588-B1 | REDUCTION OF MONOMERIC ISOCYANATES BY POROUS MATERIAL | BASF SE (DE) | 2025-08-20 | — | — | EP | disclosed |
| CN-112352334-B | Cathode for lithium-sulfur battery and cathode for sodium-sulfur battery | 约翰霍普金斯大学 | 2025-03-25 | — | — | CN | disclosed |
| US-12227526-B2 | Metal-organic framework materials comprising a diimine scaffold and methods for production thereof | ExxonMobil Technology and Engineering Company (US) | 2025-02-18 | — | — | US | disclosed |
| EP-3947396-B1 | METAL-ORGANIC FRAMEWORK MATERIALS COMPRISING A DIIMINE SCAFFOLD AND METHODS FOR PRODUCTION THEREOF | EXXONMOBIL TECHNOLOGY & ENGINEERING COMPANY (US) | 2024-12-11 | — | — | EP | disclosed |
| US-20240336636-A1 | METAL-ORGANIC FRAMEWORK | THE UNIVERSITY OF LIVERPOOL (GB) | 2024-10-10 | — | — | US | disclosed |
| US-12107210-B2 | Lithium-sulfur and sodium-sulfur battery cathodes | THE JOHNS HOPKINS UNIVERSITY (US) | 2024-10-01 | — | — | US | disclosed |
| US-20050004404-A1 | Process for the alkoxylation of monools in the presence of metallo-organic framework materials | BASF AKIENGESELLSCHAFT (DE) | 2005-01-06 | — | — | US | disclosed |
| EP-1471997-A1 | METHOD FOR STORING, ABSORBING AND EMITTING GASES USING NOVEL FRAMEWORK MATERIALS | BASF AKTIENGESELLSCHAFT (DE) | 2004-11-03 | — | — | EP | disclosed |
| WO-2004037895-A1 | PROCESS FOR PRODUCING POLYALKYLENE CARBONATES | BASF AKTIENGESELLSCHAFT (DE) | 2004-05-06 | — | — | WO | disclosed |
| WO-2003102000-A1 | SHAPED BODIES CONTAINING METAL-ORGANIC FRAMEWORKS | BASF AKTIENGESELLSCHAFT (DE) | 2003-12-11 | — | — | WO | disclosed |
| WO-2003101975-A1 | EPOXIDATION PROCESS USING CATALYSTS CONTAINING METAL ORGANIC FRAMEWORK | BASF AKTIENGESELLSCHAFT (DE) | 2003-12-11 | — | — | WO | disclosed |
| US-6624318-B1 | Process for the epoxidation of an organic compound with oxygen or an oxygen-delivering compounds using catalysts containing metal-organic frame-work materials | BASF AKTIENGESELLSCHAFT (DE) | 2003-09-23 | — | — | US | disclosed |
| US-6617467-B1 | Polymerizing carbon dioxide with an alkylene oxide in the presence of a catalytic framework material comprising pores and a metal ion with a bidentate organic compound coordinated to the ion | BASF AKTIENGESELLSCHAFT (DE) | 2003-09-09 | — | — | US | disclosed |
| WO-2003064030-A1 | METHOD FOR STORING, ABSORBING AND EMITTING GASES USING NOVEL FRAMEWORK MATERIALS | BASF AKTIENGESELLSCHAFT (DE) | 2003-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12227526-B2 | Metal-organic framework materials comprising a diimine scaffold and methods for production thereof | PICALM, ILK, CAD | TSHR 4193/4885DAO 1629/4885NAPRT 3343/4885 |
| US-12630567-B2 | High yield synthesis of metal-organic frameworks | ODC1, POF1B, DDC | TSHR 4032/4885DAO 525/4885NAPRT 763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.