SCHEMBL1661967

SCHEMBL1661967

C=C/C(=C\C(=O)O)C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.50
ALOX15 P16050 1/20 0.37
HSD17B10 Q99714 1/20 0.37
TSHR P16473 5/20 0.35
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 3/20 0.33
FGFR4 P22455 1/20 0.33
MAPK1 P28482 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
TP53 P04637 1/20 0.30
EGLN1 Q9GZT9 1/20 0.30
EGLN3 Q9H6Z9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL345324 1.00 LMNA (0.50) LMNAALOX15HSD17B10TSHRKDM4E
SCHEMBL316986 1.00 LMNA (0.50) LMNAALOX15HSD17B10TSHRKDM4E
Acetic Acid SCHEMBL3868358 0.92 LMNA (0.43) LMNAALOX15HSD17B10TSHRKDM4E
Acetic Acid SCHEMBL3868351 0.92 LMNA (0.43) LMNAALOX15HSD17B10TSHRKDM4E
Vinyl Chloride SCHEMBL6537138 0.92 LMNA (0.43) LMNAALOX15HSD17B10TSHRKDM4E
SCHEMBL28414100 0.80 LMNA (0.40) LMNAALOX15HSD17B10TSHRALDH1A1
SCHEMBL27996425 0.79 ALOX15 (0.47) LMNAALOX15HSD17B10TSHRKDM4E
Styrene SCHEMBL11119686 0.79 ALDH1A1 (0.52) LMNATSHRKDM4EALDH1A1TDP1
SCHEMBL19003733 0.78 LMNA (0.38) LMNAALOX15HSD17B10TSHRALDH1A1
SCHEMBL3189966 0.78 LMNA (0.38) LMNAALOX15HSD17B10TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11316118-B2 Dibenzo[d,B]silole-based reactive mesogens LOMOX LIMITED (GB) 2022-04-26 US claimed
EP-3523313-B1 DIBENZO[D,B]SILOLE-BASED REACTIVE MESOGENS LOMOX LTD (GB) 2021-05-05 EP claimed
US-20190280223-A1 DIBENZO[D,B]SILOLE-BASED REACTIVE MESOGENS LOMOX LIMITED (GB) 2019-09-12 US claimed
EP-3523313-A1 DIBENZO[D,B]SILOLE-BASED REACTIVE MESOGENS Lomox Limited (GB) 2019-08-14 EP claimed
WO-2018065786-A1 DIBENZO[D,B]SILOLE-BASED REACTIVE MESOGENS LOMOX LIMITED (GB) 2018-04-12 WO claimed
EP-2483367-B1 ELECTROLUMINESCENT THIOPHENE DERIVATIVES LOMOX LTD (GB) 2015-09-16 EP claimed
US-9006435-B2 Electroluminescent thiophene derivatives LOMOX LIMITED (GB) 2015-04-14 US claimed
EP-2483368-B1 ELECTROLUMINESCENT MATERIALS COMPRISING FLUORENE DERIVATIVES LOMOX LTD (GB) 2014-12-24 EP claimed
US-20120271052-A1 ELECTROLUMINESCENT THIOPHENE DERIVATIVES LOMOX LIMITED (GB) 2012-10-25 US claimed
EP-2483367-A1 ELECTROLUMINESCENT THIOPHENE DERIVATIVES Lomox Limited (GB) 2012-08-08 EP claimed
WO-2011039505-A1 ELECTROLUMINESCENT THIOPHENE DERIVATIVES LOMOX LIMITED (GB) 2011-04-07 WO claimed
CN-110382491-B Crosslinkable organometallic luminescent ligands and complexes 洛马克斯有限公司 2023-10-20 CN disclosed
US-20230123697-A1 THERAPEUTIC PATCH FOR GASTROINTESTINAL TRACT AND METHOD OF MANUFACTURING SAME INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) 2023-04-20 US disclosed
EP-3592737-B1 CROSS-LINKABLE ORGANOMETALLIC LIGHT EMITTING COMPLEXES LOMOX LTD (GB) 2022-12-21 EP disclosed
US-11316118-B2 Dibenzo[d,B]silole-based reactive mesogens LOMOX LIMITED (GB) 2022-04-26 US disclosed
US-20130037752-A1 ELECTROLUMINESCENT MATERIALS COMPRISING FLUORENE DERIVATIVES LOMOX LIMITED (GB) 2013-02-14 US disclosed
US-20120271052-A1 ELECTROLUMINESCENT THIOPHENE DERIVATIVES LOMOX LIMITED (GB) 2012-10-25 US disclosed
EP-2483368-A1 ELECTROLUMINESCENT MATERIALS COMPRISING FLUORENE DERIVATIVES Lomox Limited (GB) 2012-08-08 EP disclosed
WO-2011039506-A1 ELECTROLUMINESCENT MATERIALS COMPRISING FLUORENE DERIVATIVES LOMOX LIMITED (GB) 2011-04-07 WO disclosed
US-5371132-A A half-aromatic polyamide comprising adipic acid and isophthalic acid with hexamethylenediamine; inorganic filler; high surface gloss ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1994-12-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190280223-A1 DIBENZO[D,B]SILOLE-BASED REACTIVE MESOGENS CCNB1, CCNE2, UBE2G2 LMNA 1000/4885ALOX15 569/4885HSD17B10 345/4885
US-20120271052-A1 ELECTROLUMINESCENT THIOPHENE DERIVATIVES AR, NR2E3, NES LMNA 343/4885ALOX15 4438/4885HSD17B10 3810/4885
US-11316118-B2 Dibenzo[d,B]silole-based reactive mesogens CCNB1, CCNE2, UBE2G2 LMNA 1000/4885ALOX15 569/4885HSD17B10 345/4885
US-20130037752-A1 ELECTROLUMINESCENT MATERIALS COMPRISING FLUORENE DERIVATIVES SPIN2B, FLNB, LMNB2 LMNA 39/4885ALOX15 1074/4885HSD17B10 2175/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.