SCHEMBL16627665

SCHEMBL16627665

CCn1c(=O)c(C(=O)Nc2ccc(F)cc2)cc2c(NC(=O)Cc3ccc(C)cc3)cccc21

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.51
GAA P10253 2/20 0.51
KDM4E B2RXH2 2/20 0.48
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
NPY5R Q15761 1/20 0.47
AHR P35869 2/20 0.46
ALDH1A1 P00352 1/20 0.45
HPGD P15428 1/20 0.45
P2RX7 Q99572 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
CNR1 P21554 2/20 0.42
CNR2 P34972 1/20 0.42
RORC P51449 2/20 0.42
CCNA2 P20248 1/20 0.41
CDK2 P24941 1/20 0.41
ECE1 P42892 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16627650 0.90 AHR (0.56) SMN1; SMN2GAAKDM4EMEN1KMT2A
SCHEMBL16627759 0.85 NPY5R (0.47) SMN1; SMN2GAAKDM4EMEN1KMT2A
SCHEMBL16627823 0.84 NPY5R (0.47) KDM4EMEN1KMT2ANPY5RALDH1A1
SCHEMBL16627681 0.82 NPY5R (0.45) SMN1; SMN2KDM4EMEN1KMT2ANPY5R
SCHEMBL16627824 0.75 MEN1 (0.47) SMN1; SMN2GAAKDM4EMEN1KMT2A
SCHEMBL16627816 0.74 P2RX7 (0.48) SMN1; SMN2KDM4EAHRALDH1A1P2RX7
SCHEMBL16627691 0.74 AHR (0.42) MEN1KMT2AAHR
SCHEMBL16627757 0.74 AHR (0.72) SMN1; SMN2KDM4EMEN1KMT2AAHR
SCHEMBL16627880 0.74 HDAC1 (0.47) SMN1; SMN2KDM4EMEN1KMT2AALDH1A1
SCHEMBL16627748 0.73 AHR (0.73) SMN1; SMN2KDM4EMEN1KMT2AAHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015050379-A1 NOVEL QUINOLINONE DERIVATIVE AND USE THEREOF 광주과학기술원 2015-04-09 WO disclosed