Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1612678 | 0.84 | HPGDS (0.44) | KMT2AMEN1CYP3A4SMN1; SMN2HPGD | |
| SCHEMBL1613083 | 0.81 | CYP3A4 (0.53) | KMT2AMEN1CYP3A4SMN1; SMN2HPGD | |
| SCHEMBL20627981 | 0.81 | CA12 (0.52) | KMT2AMEN1CYP3A4SMN1; SMN2HPGD | |
| SCHEMBL8546247 | 0.79 | CYP3A4 (0.55) | HMGCRKMT2ACYP3A4SMN1; SMN2CA9 | |
| SCHEMBL12712826 | 0.76 | HPGDS (0.40) | KMT2AMEN1CYP3A4SMN1; SMN2HPGD | |
| SCHEMBL9752929 | 0.76 | HMGCR (0.50) | HMGCRKMT2AMEN1CYP3A4PTGS1 | |
| SCHEMBL1661748 | 0.75 | ALOX15 (0.38) | KMT2AMEN1CYP3A4SMN1; SMN2HPGD | |
| SCHEMBL30506419 | 0.74 | CYP3A4 (0.67) | HMGCRKMT2AMEN1CYP3A4PTGS1 | |
| SCHEMBL2874467 | 0.74 | CYP3A4 (0.67) | HMGCRKMT2AMEN1CYP3A4PTGS1 | |
| SCHEMBL8239580 | 0.73 | CA9 (0.61) | HMGCRSMN1; SMN2CA9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102007133-B | 3-phenylpyrazolo [5,1-b ] thiazole compounds | EISAI R&D MAN CO LTD | 2013-06-12 | — | — | CN | disclosed |
| EP-2487177-A1 | PYRAZOLOXAZOLE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2012-08-15 | — | — | EP | disclosed |
| EP-2487177-A1 | PYRAZOLOXAZOLE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2012-08-15 | — | — | EP | disclosed |
| US-20110086898-A1 | PYRAZOLOOXAZOLE COMPOUND | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-04-14 | — | — | US | disclosed |
| US-20110086898-A1 | PYRAZOLOOXAZOLE COMPOUND | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-04-14 | — | — | US | disclosed |
| US-20110086898-A1 | PYRAZOLOOXAZOLE COMPOUND | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-04-14 | — | — | US | disclosed |
| WO-2011043387-A1 | PYRAZOLOXAZOLE COMPOUND | エーザイ・アール・アンド・ディー・マネジメント株式会社 (JP) | 2011-04-14 | — | — | WO | disclosed |
| CN-102007133-A | 3-phenylpyrazolo [5,1-b ] thiazole compounds | EISAI R&D MAN CO LTD | 2011-04-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086898-A1 | PYRAZOLOOXAZOLE COMPOUND | CRHR1, MC2R, CRHR2 | HMGCR 4359/4885KMT2A 4639/4885MEN1 2587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.