Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycolic Acid SCHEMBL158529 | 0.89 | KDM4E (0.41) | KDM4EMEN1POLBMAPTKMT2A | |
| Malonic Acid SCHEMBL161793 | 0.89 | OPRM1 (0.43) | KDM4EMEN1POLBMAPTKMT2A | |
| SCHEMBL162104 | 0.84 | DRD2 (0.48) | DRD5DRD2DRD3HTR1AHTR7 | |
| Sulfuric Acid SCHEMBL163037 | 0.81 | LMNA (0.47) | KDM4ENOTUMDRD5DRD2DRD3 | |
| Adipic Acid SCHEMBL166309 | 0.81 | DRD2 (0.60) | KDM4EMEN1POLBMAPTKMT2A | |
| SCHEMBL164258 | 0.80 | LMNA (0.42) | NOTUMDRD5DRD2DRD3HTR1A | |
| Nitric Acid SCHEMBL161325 | 0.79 | DRD1 (0.41) | MEN1POLBMAPTKMT2ANOTUM | |
| Succinic Acid SCHEMBL170445 | 0.74 | DRD2 (0.64) | KDM4EMEN1POLBMAPTKMT2A | |
| Adipic Acid SCHEMBL161400 | 0.74 | HTR7 (0.50) | KDM4EMEN1POLBMAPTKMT2A | |
| SCHEMBL17598257 | 0.71 | HDAC3 (0.71) | KDM4EDRD2DRD3HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611781-A1 | FAST-DISSOLVE DOSAGE FORMS OF 5-HT2C AGONISTS | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | claimed |
| WO-2012030951-A1 | FAST-DISSOLVE DOSAGE FORMS OF 5-HT2C AGONISTS | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | claimed |