Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 13/20 | 0.64 |
| ▸ | DRD3 known ✓ | P35462 | 11/20 | 0.64 |
| ▸ | DRD4 known ✓ | P21917 | 9/20 | 0.64 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.49 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.49 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 12/20 | 0.64 |
| ▸ | DRD5 | P21918 | 12/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MAOA | P21397 | 2/20 | 0.59 |
| ▸ | MAOB | P27338 | 2/20 | 0.59 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL166309 | 0.93 | DRD2 (0.60) | DRD2DRD1DRD5DRD3DRD4 | |
| SCHEMBL164206 | 0.81 | DRD1 (0.85) | DRD2DRD1DRD5DRD3DRD4 | |
| SCHEMBL29391320 | 0.81 | DRD1 (0.85) | DRD2DRD1DRD5DRD3DRD4 | |
| Maleic Acid SCHEMBL167958 | 0.81 | DRD2 (0.59) | DRD2DRD1DRD5DRD3DRD4 | |
| Fumaric Acid SCHEMBL12467794 | 0.81 | DRD2 (0.59) | DRD2DRD1DRD5DRD3DRD4 | |
| Succinic Acid SCHEMBL161277 | 0.80 | NOTUM (0.54) | DRD2DRD3KDM4EMEN1POLB | |
| Succinic Acid SCHEMBL23581474 | 0.79 | TSHR (0.59) | KDM4EMEN1POLBMAPTKMT2A | |
| SCHEMBL3477555 | 0.79 | HDAC3 (0.70) | DRD2DRD3KDM4EMEN1POLB | |
| Hydrochloric Acid SCHEMBL165521 | 0.79 | MAOA (0.86) | DRD2DRD1DRD5DRD3DRD4 | |
| Iodide SCHEMBL12468173 | 0.79 | DRD1 (0.81) | DRD2DRD1DRD5DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| EP-2611427-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT& xA; | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030953-A1 | 5-HT2C RECEPTOR AGONISTS IN THE TREATMENT OF DISORDERS AMELIORATED BY REDUCTION OF NOREPINEPHRINE LEVEL | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012030927-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |