Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 4/20 | 0.36 |
| ▸ | PARP1 | P09874 | 4/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16631705 | 0.83 | TNKS (0.33) | TNKSPARP1TNKS2PARP2PARP3 | |
| SCHEMBL18081931 | 0.80 | TNKS2 (0.34) | TNKSPARP1TNKS2PARP2PARP3 | |
| SCHEMBL18080461 | 0.76 | TRPV1 (0.35) | TNKSPARP1TNKS2PARP2PARP3 | |
| SCHEMBL16631930 | 0.73 | HCAR2 (0.31) | HCAR2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL16631745 | 0.73 | HCAR2 (0.34) | TNKSPARP1TNKS2PARP2HCAR2 | |
| SCHEMBL16631471 | 0.72 | MAPK1 (0.37) | TMIGD3HPGDADORA1 | |
| SCHEMBL16631519 | 0.69 | TNKS (0.35) | TNKSPARP1TNKS2PARP2ADORA1 | |
| SCHEMBL16631495 | 0.69 | DAO (0.34) | HPGD | |
| SCHEMBL16631430 | 0.68 | KDM4E (0.36) | HCAR2HPGDCYP1A2 | |
| SCHEMBL16631918 | 0.67 | SLC9A1 (0.35) | TNKSPARP1TNKS2PARP2SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051173-A2 | POLYNUCLEOTIDE MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS, INC (US) | 2015-04-09 | — | — | WO | disclosed |