Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16631414 | 0.82 | NR1I3 (0.35) | SMN1; SMN2TP53L3MBTL1TRPA1ATM | |
| SCHEMBL18081960 | 0.79 | RAB9A (0.40) | SMN1; SMN2NPC1RAB9AATMERAP1 | |
| SCHEMBL16631769 | 0.76 | DCUN1D1 (0.33) | TP53NPC1RAB9AATMERAP1 | |
| SCHEMBL18080446 | 0.75 | NPC1 (0.32) | TP53TRPA1NPC1RAB9AATM | |
| SCHEMBL16631495 | 0.73 | DAO (0.34) | SMN1; SMN2TP53RAB9AGAAMAPT | |
| SCHEMBL16631766 | 0.73 | NAPRT (0.49) | SMN1; SMN2NPC1RAB9AGAAMAPT | |
| SCHEMBL16631471 | 0.73 | MAPK1 (0.37) | SMN1; SMN2TP53L3MBTL1TRPA1GAA | |
| SCHEMBL16631775 | 0.72 | KDM4E (0.42) | GAAMAPTKDM4EALDH1A1GABRA1 | |
| SCHEMBL6436382 | 0.67 | NISCH (0.41) | SMN1; SMN2NPC1RAB9AGAAMAPT | |
| SCHEMBL11644693 | 0.66 | SMN1; SMN2 (0.46) | SMN1; SMN2TP53NPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051173-A2 | POLYNUCLEOTIDE MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS, INC (US) | 2015-04-09 | — | — | WO | disclosed |