Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5956569 | 0.85 | RAB9A (0.55) | AURKATNKSLMNAKDM4EGABRP | |
| SCHEMBL16456379 | 0.79 | AURKA (0.53) | AURKATNKSLMNAKDM4ECDK5 | |
| SCHEMBL16634744 | 0.79 | L3MBTL1 (0.55) | AURKATNKSLMNAKDM4EGSK3B | |
| SCHEMBL16455944 | 0.76 | TNKS (0.49) | AURKATNKSLMNAKDM4ECDK5 | |
| SCHEMBL30423157 | 0.75 | GABRP (0.53) | AURKATNKSLMNAKDM4ECDK5 | |
| SCHEMBL4161172 | 0.75 | GABRP (0.53) | AURKATNKSLMNAKDM4ECDK5 | |
| SCHEMBL30792661 | 0.74 | AURKA (0.49) | AURKALMNAHSP90AA1MAPT | |
| SCHEMBL28489192 | 0.73 | AURKA (0.48) | AURKATNKSLMNAKDM4ECDK5 | |
| SCHEMBL16634626 | 0.72 | HSP90AA1 (0.54) | AURKAKDM4ERORCHSP90AA1DAO | |
| SCHEMBL21463397 | 0.72 | LMNA (0.49) | AURKATNKSLMNAKDM4ECDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |