Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 12/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634554 | 0.84 | RORC (0.55) | RORCL3MBTL1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL16634830 | 0.78 | RORC (0.43) | RORCPOLBCYP3A4CYP1A2CYP2C9 | |
| SCHEMBL16634740 | 0.77 | RORC (0.37) | RORCPOLBCYP3A4CYP1A2CYP2C9 | |
| SCHEMBL16634709 | 0.77 | TAS1R3 (0.44) | RORCCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16634643 | 0.74 | RORC (0.40) | RORCCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16634644 | 0.74 | RORC (0.40) | RORCPOLBL3MBTL1CYP3A4CYP1A2 | |
| SCHEMBL16634636 | 0.74 | RORC (0.56) | RORCCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL16634779 | 0.74 | RORC (0.53) | RORCCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16634649 | 0.73 | RORC (0.43) | RORCCYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16634721 | 0.72 | RAB9A (0.45) | RORCPOLBKMT2ATSHRCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | claimed |
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |