Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 14/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634554 | 0.84 | RORC (0.55) | RORCCYP2C9CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL16634830 | 0.83 | RORC (0.43) | RORCCYP2C9CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL16634644 | 0.80 | RORC (0.40) | RORCCYP2C9CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL16634721 | 0.79 | RAB9A (0.45) | RORCNPC1 | |
| SCHEMBL16634740 | 0.78 | RORC (0.37) | RORCCYP2C9CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL16634709 | 0.78 | TAS1R3 (0.44) | RORCCYP2C9CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL16634636 | 0.75 | RORC (0.56) | RORCCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL16634666 | 0.74 | MYC (0.48) | RORCCYP2C9CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL16634665 | 0.74 | ALDH1A1 (0.40) | — | |
| SCHEMBL16634717 | 0.72 | RORC (0.55) | RORCCYP2C9CYP3A4CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |