Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 4/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20302464 | 0.82 | L3MBTL1 (0.46) | AURKAALKTNKS2PIN1MEN1 | |
| SCHEMBL16634626 | 0.81 | HSP90AA1 (0.54) | AURKAKDM4ESMN1; SMN2HSP90AA1CYP3A4 | |
| SCHEMBL16634724 | 0.77 | TGFBR1 (0.47) | AURKAKDM4ESMN1; SMN2TNKSCYP1A2 | |
| SCHEMBL16634734 | 0.72 | DAO (0.50) | AURKAKDM4ESMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL31435021 | 0.72 | MEN1 (0.62) | KDM4ETNKSTNKS2MEN1KMT2A | |
| SCHEMBL6840233 | 0.71 | AURKA (0.52) | AURKAKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL3991350 | 0.71 | PIN1 (0.44) | TNKSTNKS2PIN1MAPT | |
| SCHEMBL5434334 | 0.71 | HSP90AA1 (0.65) | TNKSTNKS2MEN1CYP1A2HSP90AA1 | |
| SCHEMBL16634719 | 0.70 | AURKA (0.37) | AURKAKDM4ESMN1; SMN2MEN1TSHR | |
| SCHEMBL16634828 | 0.70 | RORC (0.46) | CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |