SCHEMBL16634793

SCHEMBL16634793

CC(C)(C)OC(=O)c1ccc(-n2c(=O)[nH]c3cccc(F)c32)c(F)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.43
SMN1; SMN2 Q16637 3/20 0.40
KDM4E B2RXH2 3/20 0.40
ALDH1A1 P00352 1/20 0.40
KMT2A Q03164 1/20 0.40
GABRA1 P14867 2/20 0.39
GABRG2 P18507 2/20 0.39
GABRB3 P28472 2/20 0.39
GABRA3 P34903 2/20 0.39
GABRA2 P47869 2/20 0.39
HTR7 P34969 1/20 0.37
SRD5A1 P18405 1/20 0.36
NPC1 O15118 1/20 0.36
GAA P10253 1/20 0.36
GPR119 Q8TDV5 1/20 0.35
FEN1 P39748 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16634734 0.83 DAO (0.50) DAOSMN1; SMN2KDM4EFEN1CYP3A4
SCHEMBL16634795 0.70 DAO (0.44) DAOFEN1HSP90AA1
SCHEMBL16634807 0.70 CACNA1H (0.34) SMN1; SMN2ALDH1A1KMT2AGABRA1GABRG2
SCHEMBL4208340 0.68 CES2 (0.53) KMT2AGABRA1GABRG2GABRB3GABRA3
SCHEMBL30208191 0.68 CES2 (0.53) KMT2AGABRA1GABRG2GABRB3GABRA3
SCHEMBL27903519 0.67 GABRA1 (0.43) GABRA1GABRG2GABRB3GABRA3GABRA2
SCHEMBL16634626 0.67 HSP90AA1 (0.54) DAOSMN1; SMN2KDM4EGABRA1GABRG2
SCHEMBL30289054 0.66 GABRA1 (0.50) KDM4EALDH1A1KMT2AGABRA1GABRG2
SCHEMBL30796039 0.66 L3MBTL1 (0.59) SMN1; SMN2ALDH1A1KMT2ANPC1GAA
SCHEMBL31587898 0.66 CA12 (0.46) SMN1; SMN2KDM4EALDH1A1KMT2AGABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015052675-A1 SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS GLENMARK PHARMACEUTICALS S.A. (CH) 2015-04-16 WO disclosed