Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 8/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634626 | 0.83 | HSP90AA1 (0.54) | DAOKDM4ESMN1; SMN2RORCCYP3A4 | |
| SCHEMBL16634793 | 0.83 | DAO (0.43) | DAOKDM4ESMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL16634608 | 0.79 | RORC (0.47) | DAOKDM4ESMN1; SMN2RORCCYP2C9 | |
| SCHEMBL5011347 | 0.74 | KDM4E (0.78) | KDM4ESMN1; SMN2AURKA | |
| SCHEMBL16634724 | 0.74 | TGFBR1 (0.47) | DAOKDM4ESMN1; SMN2RORCCYP3A4 | |
| SCHEMBL16634795 | 0.74 | DAO (0.44) | DAOFEN1 | |
| SCHEMBL16634859 | 0.72 | AURKA (0.44) | KDM4ESMN1; SMN2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL16634752 | 0.68 | RORC (0.56) | RORCCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5011339 | 0.65 | KDM4E (0.59) | KDM4ESMN1; SMN2 | |
| SCHEMBL21491217 | 0.65 | BCAT1 (0.55) | KDM4ESMN1; SMN2CYP2C9CYP2C19TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |