Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.61 |
| ▸ | TRAP1 | Q12931 | 5/20 | 0.56 |
| ▸ | HSP90B1 | P14625 | 4/20 | 0.56 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | CPT2 | P23786 | 1/20 | 0.45 |
| ▸ | CPT1A | P50416 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14067231 | 0.87 | ABHD6 (0.61) | ABHD6TRAP1HSP90B1SLC6A9AKR1C3 | |
| SCHEMBL30641865 | 0.86 | DRD2 (0.51) | ABHD6TRAP1HSP90B1NOTUM | |
| SCHEMBL16282734 | 0.83 | ABHD6 (0.61) | ABHD6TRAP1HSP90B1SLC6A9AKR1C3 | |
| SCHEMBL16637999 | 0.81 | ABHD6 (0.65) | ABHD6TRAP1HSP90B1SLC6A9NOTUM | |
| SCHEMBL26923232 | 0.80 | ABHD6 (0.48) | ABHD6TRAP1HSP90B1SLC6A9 | |
| SCHEMBL7946982 | 0.80 | TRAP1 (0.52) | ABHD6TRAP1SLC6A9NOTUMTAS1R3 | |
| SCHEMBL6229746 | 0.78 | ABHD6 (0.55) | ABHD6TRAP1HSP90B1SLC6A9CPT2 | |
| SCHEMBL20658793 | 0.78 | L3MBTL1 (0.44) | ABHD6TRAP1HSP90B1 | |
| SCHEMBL14067047 | 0.77 | NOTUM (0.58) | ABHD6TRAP1HSP90B1NOTUMMTNR1A | |
| SCHEMBL7007674 | 0.77 | ABHD6 (0.64) | ABHD6TRAP1HSP90B1AKR1C3CPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055301-B1 | (2-(5-ISOINDOLIN-2-YL)PYRIMIDIN-4-YL)-AMINE DERIVATIVES AS RHO KINASE INHIBITORS FOR TREATING AUTOIMMUNE DISEASES | KADMON CORP LLC (US) | 2019-11-20 | — | — | EP | disclosed |
| US-10125144-B2 | Rho kinase inhibitors | KADMON CORPORATION, LLC (US) | 2018-11-13 | — | — | US | disclosed |
| US-20160237095-A1 | RHO KINASE INHIBITORS | KADMON CORPORATION, LLC | 2016-08-18 | — | — | US | disclosed |
| EP-3055301-A1 | RHO KINASE INHIBITORS | Kadmon Corporation, LLC (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015054317-A1 | RHO KINASE INHIBITORS | KADMON CORPORATION, LLC (US) | 2015-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160237095-A1 | RHO KINASE INHIBITORS | ROCK2, ROCK1, RHOA | ABHD6 4481/4885TRAP1 1554/4885HSP90B1 2353/4885 |
| US-10125144-B2 | Rho kinase inhibitors | ROCK2, ROCK1, RHOA | ABHD6 4481/4885TRAP1 1554/4885HSP90B1 2353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.