Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10179501 | 0.87 | PSIP1 (0.52) | PSIP1CA2BRD4HSD11B1HDAC4 | |
| SCHEMBL10179856 | 0.85 | HDAC4 (0.53) | PSIP1CA2BRD4HSD11B1HDAC4 | |
| SCHEMBL18685337 | 0.84 | PSIP1 (0.48) | PSIP1CA2BRD4HSD11B1HDAC4 | |
| SCHEMBL18713459 | 0.81 | PSIP1 (0.50) | PSIP1BRD4HSD11B1HDAC4HDAC2 | |
| SCHEMBL22181477 | 0.81 | ALDH1A1 (0.46) | CA2GAATRPV4ALDH1A1 | |
| SCHEMBL17263850 | 0.80 | PSIP1 (0.68) | PSIP1CA2BRD4HSD11B1GAA | |
| SCHEMBL18602273 | 0.78 | PSIP1 (0.43) | PSIP1CA2BRD4HSD11B1HDAC4 | |
| SCHEMBL12302897 | 0.78 | PSIP1 (0.43) | PSIP1CA2BRD4HSD11B1HDAC4 | |
| SCHEMBL23364593 | 0.77 | CA2 (0.61) | CA2 | |
| SCHEMBL22545458 | 0.77 | CA2 (0.38) | CA2HSD11B1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150105396-A1 | Chemical Compounds | PFIZER LTD (GB) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105396-A1 | Chemical Compounds | GABRA5, GABRA4, GABRA3 | PSIP1 3000/4885CA2 599/4885BRD4 803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.