Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 7/20 | 1.00 |
| ▸ | PPME1 | Q9Y570 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15175998 | 0.85 | RAPGEF4 (1.00) | RAPGEF4ALDH1A1PKMALDH3A1HTR6 | |
| SCHEMBL10466733 | 0.85 | RAPGEF4 (0.76) | RAPGEF4PPME1ALDH1A1HTR6 | |
| SCHEMBL16653266 | 0.81 | RAPGEF4 (1.00) | RAPGEF4ALDH1A1PKMHTR6MMP2 | |
| SCHEMBL15173806 | 0.80 | RAPGEF4 (0.68) | RAPGEF4ALDH1A1HTR6 | |
| SCHEMBL15176640 | 0.77 | RAPGEF4 (1.00) | RAPGEF4ALDH1A1KDM4EMAPTNPSR1 | |
| SCHEMBL5534938 | 0.74 | RAPGEF4 (0.74) | RAPGEF4PKMALDH3A1HTR6MMP2 | |
| SCHEMBL15174827 | 0.73 | RAPGEF4 (1.00) | RAPGEF4ALDH1A1MAPTNPSR1 | |
| SCHEMBL10467848 | 0.72 | RAPGEF4 (0.58) | RAPGEF4PPME1ALDH1A1HTR6 | |
| SCHEMBL3964674 | 0.72 | PPME1 (0.58) | RAPGEF4PPME1ALDH1A1PKMALDH3A1 | |
| SCHEMBL15176061 | 0.71 | RAPGEF4 (1.00) | RAPGEF4ALDH1A1KDM4EMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2811990-B1 | MODULATORS OF EXCHANGE PROTEINS DIRECTLY ACTIVATED BY CAMP (EPACS) | UNIV TEXAS (US) | 2017-10-25 | — | — | EP | disclosed |
| EP-2811990-B1 | MODULATORS OF EXCHANGE PROTEINS DIRECTLY ACTIVATED BY CAMP (EPACS) | UNIV TEXAS (US) | 2017-10-25 | — | — | EP | disclosed |
| US-9539256-B2 | Modulators of exchange proteins directly activated by cAMP (EPACS) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-01-10 | — | — | US | disclosed |
| US-9539256-B2 | Modulators of exchange proteins directly activated by cAMP (EPACS) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-01-10 | — | — | US | disclosed |
| US-9539256-B2 | Modulators of exchange proteins directly activated by cAMP (EPACS) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-01-10 | — | — | US | disclosed |
| US-20150110809-A1 | MODULATORS OF EXCHANGE PROTEINS DIRECTLY ACTIVATED BY CAMP (EPACS) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-04-23 | — | — | US | disclosed |
| US-20150110809-A1 | MODULATORS OF EXCHANGE PROTEINS DIRECTLY ACTIVATED BY CAMP (EPACS) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-04-23 | — | — | US | disclosed |
| US-20150110809-A1 | MODULATORS OF EXCHANGE PROTEINS DIRECTLY ACTIVATED BY CAMP (EPACS) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150110809-A1 | MODULATORS OF EXCHANGE PROTEINS DIRECTLY ACTIVATED BY CAMP (EPACS) | RAPGEF3, RAPGEF4, CREB1 | RAPGEF4 2/4885PPME1 508/4885ALDH1A1 3892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.