Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPME1 | Q9Y570 | 7/20 | 0.58 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | APEH | P13798 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616366 | 0.84 | PPME1 (0.60) | PPME1ALDH1A1APEHKMT2A | |
| SCHEMBL2457308 | 0.83 | RAPGEF4 (0.58) | PPME1RAPGEF4PKMALDH3A1ALDH1A1 | |
| SCHEMBL3968075 | 0.83 | PPME1 (0.55) | PPME1RAPGEF4PKMALDH3A1APEH | |
| SCHEMBL3964676 | 0.83 | PPME1 (0.45) | PPME1RAPGEF4APEHCYP3A4 | |
| SCHEMBL3966831 | 0.83 | MET (0.49) | PPME1PKMALDH1A1MMP2CYP3A4 | |
| SCHEMBL3967048 | 0.80 | PPME1 (0.43) | PPME1RAPGEF4ALDH1A1APEH | |
| SCHEMBL3969097 | 0.76 | NOD1 (0.43) | PPME1RAPGEF4APEHMMP2ACHE | |
| SCHEMBL3968076 | 0.75 | MET (0.47) | PPME1RAPGEF4ALDH1A1CYP3A4KMT2A | |
| SCHEMBL16653247 | 0.72 | RAPGEF4 (1.00) | PPME1RAPGEF4PKMALDH3A1ALDH1A1 | |
| SCHEMBL5247297 | 0.71 | RAPGEF4 (0.60) | PPME1RAPGEF4ALDH1A1APEHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |