Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16654083 | 0.86 | ALDH1A1 (0.52) | OPRM1TSHRALDH1A1KMT2ANPC1 | |
| SCHEMBL1474547 | 0.69 | NOTUM (0.59) | TSHRALDH1A1KMT2AEPHX2SCD5 | |
| SCHEMBL16654037 | 0.69 | SLC6A9 (0.46) | OPRM1TSHRALDH1A1KMT2ANPC1 | |
| SCHEMBL1475165 | 0.68 | ALDH1A1 (0.62) | ALDH1A1KMT2AEPHX2SCDSCD5 | |
| SCHEMBL16654340 | 0.67 | ALDH1A1 (0.54) | OPRM1TSHRALDH1A1KMT2ANPC1 | |
| SCHEMBL31098717 | 0.67 | OPRM1 (0.47) | OPRM1TSHRALDH1A1KMT2ANPC1 | |
| SCHEMBL10274628 | 0.66 | RAB9A (0.51) | TSHRALDH1A1KMT2AEPHX2NPC1 | |
| SCHEMBL20507209 | 0.66 | RAB9A (0.52) | TSHRALDH1A1KMT2AEPHX2NPC1 | |
| SCHEMBL1477034 | 0.66 | EPHX2 (0.47) | TSHRALDH1A1KMT2AEPHX2NPC1 | |
| SCHEMBL14174990 | 0.66 | OPRM1 (0.46) | OPRM1TSHRALDH1A1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160255836-A1 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-09-08 | — | — | US | claimed |
| EP-3057423-A2 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2016-08-24 | — | — | EP | claimed |
| WO-2015055706-A2 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-04-23 | — | — | WO | claimed |
| US-10076116-B2 | N-cycloalkyl-N-(biheterocyclymethylene)-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-09-18 | — | — | US | disclosed |
| US-20160255836-A1 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-09-08 | — | — | US | disclosed |
| EP-3057423-A2 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015055706-A2 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10076116-B2 | N-cycloalkyl-N-(biheterocyclymethylene)-(thio)carboxamide derivatives | CBR3, CYP51A1, NIT2 | OPRM1 4595/4885TSHR 2593/4885ALDH1A1 3279/4885 |
| US-20160255836-A1 | N-CYCLOALKYL-N-(BIHETEROCYCLYMETHYLENE)-(THIO)CARBOXAMIDE DERIVATIVES | CBR3, CYP51A1, NIT2 | OPRM1 4595/4885TSHR 2593/4885ALDH1A1 3279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.