Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1561802 | 0.80 | TSHR (0.56) | S100A4TRPV1CTSBERN1PKM | |
| SCHEMBL24508 | 0.78 | S100A4 (0.56) | S100A4TRPV1CTSBERN1PKM | |
| SCHEMBL29395434 | 0.78 | S100A4 (0.56) | S100A4TRPV1CTSBERN1PKM | |
| SCHEMBL204357 | 0.78 | S100A4 (0.61) | S100A4TRPV1CTSBERN1PKM | |
| SCHEMBL3282011 | 0.77 | S100A4 (0.50) | S100A4TRPV1CTSBERN1PKM | |
| SCHEMBL7524 | 0.75 | HPGD (0.62) | S100A4TRPV1CTSBERN1MAPK1 | |
| SCHEMBL489333 | 0.75 | S100A4 (0.49) | S100A4TRPV1CTSBERN1PKM | |
| SCHEMBL4228733 | 0.75 | S100A4 (0.49) | S100A4TRPV1CTSBERN1PKM | |
| SCHEMBL405513 | 0.75 | PARP1 (0.53) | S100A4TRPV1CTSBERN1PKM | |
| SCHEMBL120973 | 0.75 | TDP1 (0.64) | S100A4TRPV1CTSBPKMCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057943-A1 | PYRIMIDINE FGFR4 INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |