SCHEMBL1665866

SCHEMBL1665866

FC(F)COc1cnccc1-c1nc2cc(C(F)(F)F)cnc2s1

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
BUB1 O43683 5/20 0.34
CYP1A2 P05177 1/20 0.33
METAP2 P50579 1/20 0.33
AAK1 Q2M2I8 2/20 0.33
CYP17A1 P05093 1/20 0.33
ILK Q13418 1/20 0.32
S1PR1 P21453 1/20 0.32
GPBAR1 Q8TDU6 2/20 0.31
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11895090 0.87 NPSR1 (0.37) CYP1A2METAP2AAK1ILKS1PR1
SCHEMBL1665867 0.85 CYP1A2 (0.46) CYP1A2METAP2AAK1GPBAR1HPGD
SCHEMBL11953201 0.85 CYP17A1 (0.38) BUB1CYP17A1
SCHEMBL11894648 0.79 CYP1A2 (0.41) CYP1A2METAP2AAK1ILKS1PR1
SCHEMBL11895093 0.78 RAB9A (0.39) CYP1A2ILKHPGD
SCHEMBL1026375 0.77 SGMS2 (0.34) BUB1CYP1A2METAP2CYP17A1S1PR1
SCHEMBL11895332 0.77 POLB (0.33) CYP1A2METAP2ILKS1PR1GPBAR1
SCHEMBL117897 0.76 POLB (0.42) BUB1CYP1A2METAP2CYP17A1
SCHEMBL11894951 0.76 ILK (0.34) CYP1A2METAP2CYP17A1ILKS1PR1
SCHEMBL16612971 0.75 SLC22A12 (0.33) ILKS1PR1GPBAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2486035-B1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL CO (JP) 2015-08-26 EP disclosed
US-8742112-B2 Heterocyclic compound and its use for control of an arthropod pest SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-06-03 US disclosed
US-8742112-B2 Heterocyclic compound and its use for control of an arthropod pest SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-06-03 US disclosed
EP-2486035-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST Sumitomo Chemical Co., Ltd (JP) 2012-08-15 EP disclosed
US-20120196891-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-02 US disclosed
US-20120196891-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-02 US disclosed
WO-2011043404-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-04-14 WO disclosed
WO-2011043404-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-04-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120196891-A1 HETEROCYCLIC COMPOUND AND ITS USE FOR CONTROL OF AN ARTHROPOD PEST HAAO, DDT, ACHE BUB1 3350/4885CYP1A2 7/4885METAP2 3749/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.