Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGFR | P43088 | 3/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13282525 | 0.84 | CNR2 (0.48) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL28095641 | 0.81 | MEN1 (0.47) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL13285509 | 0.76 | CYP2C19 (0.50) | POLBMAPTMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL16664374 | 0.75 | GPR139 (0.46) | HPGDMAPTTSHRALDH1A1HTT | |
| SCHEMBL13240844 | 0.75 | MMP2 (0.50) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL1695578 | 0.75 | MMP2 (0.50) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL8873187 | 0.75 | SLC1A1 (0.56) | MEN1KMT2APPARA | |
| SCHEMBL12074612 | 0.74 | CASP3 (0.41) | MEN1KMT2ARAB9ANPC1HPGD | |
| SCHEMBL22338178 | 0.73 | PTGFR (0.46) | KDM4EMAPTMAPK1PTGFRALDH1A1 | |
| SCHEMBL9285815 | 0.73 | SMN1; SMN2 (0.56) | MEN1KMT2ARAB9ANPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376489-B1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMA SPA (IT) | 2015-04-22 | — | — | EP | disclosed |