SCHEMBL28095641

SCHEMBL28095641

O=C(C(CNc1cccc(F)c1)c1ccc(Cl)cc1)C(CNc1cccc(F)c1)c1ccc(Cl)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
RAB9A P51151 3/20 0.47
NPC1 O15118 2/20 0.45
LMNA P02545 2/20 0.43
MAPT P10636 3/20 0.43
TSHR P16473 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
SMN1; SMN2 Q16637 5/20 0.42
NPSR1 Q6W5P4 2/20 0.42
GAA P10253 2/20 0.42
XBP1 P17861 1/20 0.42
CNR1 P21554 1/20 0.41
GRIK1 P39086 1/20 0.41
OPRM1 P35372 1/20 0.41
ALDH1A1 P00352 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28095284 0.83 SLC6A3 (0.46) KMT2ARAB9ALMNASMN1; SMN2CNR1
SCHEMBL27871833 0.83 ADRB2 (0.44) CNR1PPARA
SCHEMBL16664416 0.81 MEN1 (0.46) MEN1KMT2ARAB9ANPC1MAPT
SCHEMBL28095286 0.75 CYP1A2 (0.43) MEN1KMT2ARAB9ANPC1LMNA
SCHEMBL28044003 0.71 ALDH1A1 (0.45) MEN1KMT2ALMNAMAPTCYP1A2
SCHEMBL13282525 0.70 CNR2 (0.48) MEN1KMT2ARAB9ANPC1MAPT
SCHEMBL1432517 0.70 MEN1 (0.47) MEN1KMT2ARAB9ANPC1MAPT
SCHEMBL12218440 0.69 RAB9A (0.79) MEN1KMT2ARAB9ANPC1LMNA
SCHEMBL28095287 0.68 CNR1 (0.49) MEN1KMT2AMAPTSMN1; SMN2CNR1
Bicarbonate SCHEMBL1432516 0.67 MEN1 (0.54) MEN1KMT2ARAB9ANPC1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106243053-A A kind of triazolylamide ketone antibacterial, synthetic method and application thereof 三峡大学 2016-12-21 CN disclosed