Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 6/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15343201 | 0.90 | PIK3CA (0.41) | HRH3SYKTBK1IRAK4TDO2 | |
| SCHEMBL19355418 | 0.80 | CYP1A2 (0.46) | SYK | |
| SCHEMBL16664942 | 0.79 | SYK (0.49) | HRH4SYKTBK1TDO2 | |
| SCHEMBL17634513 | 0.79 | CYP1A2 (0.41) | SYKIRAK4 | |
| SCHEMBL19905357 | 0.76 | CYP2D6 (0.39) | SYKIRAK4 | |
| SCHEMBL16664930 | 0.76 | GPR39 (0.42) | HRH4HRH3 | |
| SCHEMBL16665019 | 0.76 | TDO2 (0.44) | SYKTBK1TDO2CCR6 | |
| SCHEMBL16660261 | 0.75 | PIK3CA (0.46) | HRH4 | |
| SCHEMBL19819913 | 0.75 | HPGDS (0.44) | HRH4SYKTBK1TDO2 | |
| SCHEMBL19905240 | 0.74 | SYK (0.41) | HRH4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015058031-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-04-23 | — | — | WO | disclosed |