SCHEMBL1666912

SCHEMBL1666912

C=CCc1cccc([C]=O)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 1/20 0.41
ALDH1A1 P00352 5/20 0.40
GABRA1 P14867 4/20 0.40
GABRB2 P47870 4/20 0.40
MAPT P10636 3/20 0.40
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
CNR2 P34972 3/20 0.40
PPARG P37231 2/20 0.40
PPARD Q03181 2/20 0.40
GAA P10253 2/20 0.40
CNR1 P21554 2/20 0.40
KDM4E B2RXH2 1/20 0.40
ALDH2 P05091 1/20 0.40
AKR1B1 P15121 1/20 0.40
HPGD P15428 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
PTGS2 P35354 1/20 0.40
CYP3A4 P08684 5/20 0.38
CYP2D6 P10635 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28119736 0.82 XDH (0.45) XDHALDH1A1GABRA1GABRB2MAPT
SCHEMBL3485106 0.81 XDH (0.41) XDHALDH1A1GABRA1GABRB2MAPT
SCHEMBL2162055 0.81 GLA (0.46) XDHALDH1A1GABRA1GABRB2MAPT
SCHEMBL1325860 0.79 XDH (0.54) XDHALDH1A1GABRA1GABRB2MAPT
Water SCHEMBL28099990 0.77 XDH (0.52) XDHALDH1A1GABRA1GABRB2MAPT
Ethylene SCHEMBL28753621 0.77 XDH (0.52) XDHALDH1A1GABRA1GABRB2MAPT
SCHEMBL6919173 0.75 ALDH1A1 (0.47) XDHALDH1A1GABRA1GABRB2MAPT
SCHEMBL2838377 0.74 PNMT (0.48) ALDH1A1CYP3A4CYP2D6CYP2C9CYP1A2
SCHEMBL910601 0.74 MGLL (0.43) ALDH1A1GABRA1GABRB2MAPTMEN1
SCHEMBL10490628 0.74 GLA (0.35) MEN1KMT2AL3MBTL1GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4868241-A POLYVINYL ALCOHOL MODIFIED WITH BENZOIC ACID DERIVATIVE AMERICAN CYANAMID COMPANY (US) 1989-09-19 US claimed
EP-0231922-A2 Electron beam and X-ray resists AMERICAN CYANAMID COMPANY (US) 1987-08-12 EP claimed
US-9648879-B2 Co-crystal and method for producing same NIPPON SODA CO., LTD. (JP) 2017-05-16 US disclosed
US-20160278380-A1 CO-CRYSTAL AND METHOD FOR PRODUCING SAME NIPPON SODA CO., LTD. (JP) 2016-09-29 US disclosed
EP-3069610-A1 CO-CRYSTAL AND METHOD FOR PRODUCING SAME Nippon Soda Co., Ltd. (JP) 2016-09-21 EP disclosed
EP-2314583-B1 NITROGENATED HETEROCYCLIC DERIVATIVE, AND AGRICULTURAL OR HORTICULTURAL BACTERICIDAL AGENT NIPPON SODA CO (JP) 2015-02-25 EP disclosed
US-8557738-B2 Nitrogen-containing heterocyclic derivative and fungicide for agricultural and horticultural use NIPPON SODA CO., LTD. (JP) 2013-10-15 US disclosed
US-20110136782-A1 NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE AND FUNGICIDE FOR AGRICULTURAL AND HORTICULTURAL USE NIPPON SODA CO., LTD (JP) 2011-06-09 US disclosed
EP-2314583-A1 NITROGENATED HETEROCYCLIC DERIVATIVE, AND AGRICULTURAL OR HORTICULTURAL BACTERICIDAL AGENT Nippon Soda Co., Ltd. (JP) 2011-04-27 EP disclosed
EP-0966454-A1 DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS Boehringer Ingelheim Pharma KG (DE) 1999-12-29 EP disclosed
WO-1998037075-A1 DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA KG (DE) 1998-08-27 WO disclosed
US-4868241-A POLYVINYL ALCOHOL MODIFIED WITH BENZOIC ACID DERIVATIVE AMERICAN CYANAMID COMPANY (US) 1989-09-19 US disclosed
EP-0231922-A2 Electron beam and X-ray resists AMERICAN CYANAMID COMPANY (US) 1987-08-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160278380-A1 CO-CRYSTAL AND METHOD FOR PRODUCING SAME DDT, CCDC22, MLN XDH 738/4885ALDH1A1 4541/4885GABRA1 4385/4885
US-20110136782-A1 NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE AND FUNGICIDE FOR AGRICULTURAL AND HORTICULTURAL USE CBR3, NOS1, CBR1 XDH 78/4885ALDH1A1 2698/4885GABRA1 1394/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.