Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 3/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL25355214 | 0.98 | NR1H2 (0.35) | NR1H2NR1H3RORCNR1I2 | |
| SCHEMBL985526 | 0.98 | NR1H2 (0.36) | NR1H2NR1H3RORCNR1I2 | |
| Lithium Ion SCHEMBL1451369 | 0.96 | NR1H2 (0.36) | NR1H2NR1H3RORCNR1I2 | |
| SCHEMBL707718 | 0.96 | NR1H2 (0.36) | NR1H2NR1H3RORCNR1I2 | |
| Water SCHEMBL15066604 | 0.96 | NR1H2 (0.36) | NR1H2NR1H3RORCNR1I2 | |
| SCHEMBL1451577 | 0.96 | NR1H2 (0.36) | NR1H2NR1H3RORCNR1I2 | |
| SCHEMBL7148800 | 0.96 | NR1H2 (0.36) | NR1H2NR1H3RORCNR1I2 | |
| Silver SCHEMBL1450737 | 0.96 | NR1H2 (0.36) | NR1H2NR1H3RORCNR1I2 | |
| Water SCHEMBL1450812 | 0.94 | NR1H2 (0.35) | NR1H2NR1H3RORCNR1I2 | |
| SCHEMBL984942 | 0.92 | NR1H2 (0.34) | NR1H2NR1H3RORCNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150119848-A1 | METHOD AND DEVICE FOR DETECTION OF BIOAVAILABLE DRUG CONCENTRATION | THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2015-04-30 | — | — | US | claimed |
| EP-3629928-B1 | METHOD AND DEVICE FOR DETECTION OF BIOAVAILABLE DRUG CONCENTRATION IN A FLUID SAMPLE | THE UNIV OF TENNESSEE RESEARCH FOUNDATION (US) | 2025-11-05 | — | — | EP | disclosed |
| US-11686722-B2 | Compositions and methods to detect molecules in a sample | INFUSENSE CORP. (US) | 2023-06-27 | — | — | US | disclosed |
| US-11375929-B2 | Method and device for detection of bioavailable drug concentration in a fluid sample | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2022-07-05 | — | — | US | disclosed |
| US-20190331656-A1 | COMPOSITIONS AND METHODS TO DETECT MOLECULES IN A SAMPLE | INFUSENSE CORP. | 2019-10-31 | — | — | US | disclosed |
| US-20180271413-A1 | METHOD AND DEVICE FOR DETECTION OF BIOAVAILABLE DRUG CONCENTRATION IN A FLUID SAMPLE | UNITED STATES GOVERNMENT | 2018-09-27 | — | — | US | disclosed |
| US-9983162-B2 | Method and device for detection of bioavailable drug concentration | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2018-05-29 | — | — | US | disclosed |
| US-20150119848-A1 | METHOD AND DEVICE FOR DETECTION OF BIOAVAILABLE DRUG CONCENTRATION | THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2015-04-30 | — | — | US | disclosed |