Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 3/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL25355214 | 0.98 | NR1H2 (0.35) | NR1H2NR1H3RORCNR1I2 | |
| Water SCHEMBL1450812 | 0.98 | NR1H2 (0.35) | NR1H2NR1H3RORCNR1I2 | |
| SCHEMBL985526 | 0.98 | NR1H2 (0.36) | NR1H2NR1H3RORCNR1I2 | |
| SCHEMBL1451577 | 0.96 | NR1H2 (0.36) | NR1H2NR1H3RORCNR1I2 | |
| SCHEMBL707718 | 0.96 | NR1H2 (0.36) | NR1H2NR1H3RORCNR1I2 | |
| SCHEMBL7148800 | 0.96 | NR1H2 (0.36) | NR1H2NR1H3RORCNR1I2 | |
| Lithium Ion SCHEMBL1451369 | 0.96 | NR1H2 (0.36) | NR1H2NR1H3RORCNR1I2 | |
| Silver SCHEMBL1450737 | 0.96 | NR1H2 (0.36) | NR1H2NR1H3RORCNR1I2 | |
| Potassium Ion SCHEMBL16669355 | 0.96 | NR1H2 (0.36) | NR1H2NR1H3RORCNR1I2 | |
| SCHEMBL984942 | 0.92 | NR1H2 (0.34) | NR1H2NR1H3RORCNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154326-A1 | SENSOR FOR MEASURING IONIZED MAGNESIUM | INSTRUMENTATION LABORATORY COMPANY (US) | 2023-08-17 | — | — | WO | disclosed |
| EP-3247709-A1 | CALIXPYRROLE COMPOUNDS AND CREATININE-SELECTIVE ELECTRODES COMPRISING THEM | Fundació Institut Català D'investigació Quimica (ES) | 2017-11-29 | — | — | EP | disclosed |
| WO-2016116175-A1 | CALIXPYRROLE COMPOUNDS AND CREATININE-SELECTIVE ELECTRODES COMPRISING THEM | FUNDACIÓ INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA (ICIQ) (ES) | 2016-07-28 | — | — | WO | disclosed |
| EP-2797509-A1 | ANALYTE SENSOR WITH EXTENDED RANGE OF DETECTION | Wellsense, Inc. (US) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013102162-A1 | ANALYTE SENSOR WITH EXTENDED RANGE OF DETECTION | WELLSENSE, INC. (US) | 2013-07-04 | — | — | WO | disclosed |
| WO-2013102161-A1 | ANALYTE SENSOR | WELLSENSE, INC. (US) | 2013-07-04 | — | — | WO | disclosed |