Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | MMP12 | P39900 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.36 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20582493 | 0.78 | L3MBTL1 (0.40) | ALDH1A1KMT2ASMN1; SMN2GSK3BDAO | |
| SCHEMBL29210322 | 0.75 | NQO1 (0.33) | SMN1; SMN2NQO1CYP1A2 | |
| SCHEMBL28649609 | 0.75 | ICAM1 (0.39) | ALDH1A1KMT2AHTTRAB9ASMN1; SMN2 | |
| SCHEMBL4086194 | 0.75 | F2 (0.52) | F2ALDH1A1KMT2AHTTRAB9A | |
| SCHEMBL1715239 | 0.74 | — | — | |
| SCHEMBL7747781 | 0.74 | ALDH1A1 (0.43) | F2ALDH1A1KMT2AHTTRAB9A | |
| SCHEMBL7931020 | 0.73 | ALDH1A1 (0.39) | F2ALDH1A1KMT2AHTTRAB9A | |
| SCHEMBL28663727 | 0.73 | LOX (0.47) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL18641383 | 0.73 | KDM4E (0.56) | ALDH1A1KMT2ARAB9ASMN1; SMN2POLB | |
| SCHEMBL29032403 | 0.72 | KDM4E (0.50) | ALDH1A1KMT2ARAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10301348-B2 | Compounds for use in prevention and treatment of neurodegenerative diseases and pain | ACADEMIA SINICA (TW) | 2019-05-28 | — | — | US | disclosed |
| EP-3060566-B1 | COMPOUNDS FOR USE IN PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES AND PAIN | ACADEMIA SINICA (TW) | 2018-09-05 | — | — | EP | disclosed |
| US-20160264613-A1 | COMPOUNDS FOR USE IN PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES AND PAIN | ACADEMIA SINICA (TW) | 2016-09-15 | — | — | US | disclosed |
| EP-3060566-A1 | COMPOUNDS FOR USE IN PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES AND PAIN | Academia Sinica (TW) | 2016-08-31 | — | — | EP | disclosed |
| WO-2015061426-A1 | COMPOUNDS FOR USE IN PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES AND PAIN | ACADEMIA SINICA (TW) | 2015-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264613-A1 | COMPOUNDS FOR USE IN PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES AND PAIN | ADORA2A, ADORA3, ADORA2B | F2 4682/4885ALDH1A1 744/4885KMT2A 338/4885 |
| US-10301348-B2 | Compounds for use in prevention and treatment of neurodegenerative diseases and pain | ADORA2A, ADORA3, ADORA2B | F2 4682/4885ALDH1A1 744/4885KMT2A 338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.