Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP14 | P54578 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 7/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667847 | 0.83 | USP14 (0.46) | USP14KDM4EELANEFEN1 | |
| SCHEMBL1667710 | 0.81 | USP14 (0.39) | USP14KDM4EKDM4DELANE | |
| SCHEMBL1667713 | 0.81 | USP14 (0.39) | USP14KDM4EKDM4DELANE | |
| SCHEMBL1667576 | 0.80 | KDM4E (0.41) | USP14KDM4EKDM4DELANEFEN1 | |
| SCHEMBL1667769 | 0.78 | ELANE (0.39) | USP14KDM4EKDM4DELANEPIK3CG | |
| SCHEMBL12797301 | 0.77 | HSP90AA1 (0.41) | USP14KDM4EFEN1ALDH1A1TSHR | |
| SCHEMBL1667598 | 0.77 | ELANE (0.38) | USP14KDM4EKDM4DELANEPIK3CG | |
| SCHEMBL1667597 | 0.77 | ELANE (0.38) | USP14KDM4EKDM4DELANEPIK3CG | |
| SCHEMBL1667600 | 0.77 | ELANE (0.38) | USP14KDM4EKDM4DELANEPIK3CG | |
| SCHEMBL1667776 | 0.76 | NTRK1 (0.37) | USP14KDM4EFEN1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042474-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | claimed |
| WO-2011042474-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |
| WO-2011042474-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |