Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16684943 | 0.86 | HPGD (0.41) | GAAADRA1APOLBADRA1DADRA1B | |
| SCHEMBL16684946 | 0.85 | ALOX5 (0.37) | PDK2POLB | |
| SCHEMBL16684794 | 0.84 | KDM4E (0.33) | — | |
| SCHEMBL16685117 | 0.73 | HTR2A (0.38) | — | |
| SCHEMBL16684950 | 0.69 | DRD2 (0.41) | LMNAPOLB | |
| SCHEMBL16685002 | 0.64 | ALOX5 (0.39) | PDK2LMNAPOLB | |
| SCHEMBL19962170 | 0.62 | PLK1 (0.59) | GAAPDK2PLK1 | |
| SCHEMBL18176054 | 0.62 | PLK1 (0.50) | GAAADRA1AADRA2APDK2PLK1 | |
| SCHEMBL21268576 | 0.61 | ALDH1A1 (0.38) | — | |
| SCHEMBL16684902 | 0.61 | ALOX5 (0.43) | LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066344-A1 | 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE | ARENA PHARMACEUTICALS, INC. (US) | 2015-05-07 | — | — | WO | disclosed |