Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1670835 | 0.94 | OPRM1 (0.43) | NAMPTMAPTTP53OPRM1ADRA1A | |
| Trifluoroacetic Acid SCHEMBL1670822 | 0.83 | ITGB3 (0.42) | NAMPTMAPTTP53HPGDCA1 | |
| SCHEMBL1668720 | 0.82 | CHRM5 (0.43) | OPRM1ADRA1ADRD4OPRD1OPRK1 | |
| SCHEMBL12801195 | 0.81 | KDM4E (0.42) | NAMPTOPRD1OPRK1 | |
| SCHEMBL12801253 | 0.81 | NAMPT (0.37) | NAMPTMAPTTP53OPRM1ADRA1A | |
| SCHEMBL12801191 | 0.80 | CHRM5 (0.46) | OPRM1ADRA1ADRD4OPRD1OPRK1 | |
| Trifluoroacetic Acid SCHEMBL1670826 | 0.79 | ITGB3 (0.41) | TP53OPRM1POLBCA2 | |
| SCHEMBL12801259 | 0.78 | OPRM1 (0.42) | MAPTTP53OPRM1OPRD1OPRK1 | |
| SCHEMBL1670823 | 0.76 | ITGB3 (0.36) | NAMPTMAPTTP53HPGD | |
| SCHEMBL12800770 | 0.76 | OPRD1 (0.42) | NAMPTMAPTOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011048409-A1 | CYCLIC AMINE DERIVATIVES HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | ASTRAZENECA AB (SE) | 2011-04-28 | — | — | WO | disclosed |
| WO-2011048409-A1 | CYCLIC AMINE DERIVATIVES HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | ASTRAZENECA AB (SE) | 2011-04-28 | — | — | WO | disclosed |