Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 3/20 | 0.68 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.68 |
| ▸ | PPARG | P37231 | 3/20 | 0.68 |
| ▸ | PPARD | Q03181 | 3/20 | 0.68 |
| ▸ | PPARA | Q07869 | 3/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | BLM | P54132 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | FABP4 | P15090 | 2/20 | 0.68 |
| ▸ | FAAH | O00519 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | F7 | P08709 | 2/20 | 0.68 |
| ▸ | F3 | P13726 | 2/20 | 0.68 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.68 |
| ▸ | GMNN | O75496 | 1/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10521045 | 1.00 | TERT (0.68) | TERTPTPN1PPARGPPARDPPARA | |
| SCHEMBL220791 | 1.00 | TERT (0.68) | TERTPTPN1PPARGPPARDPPARA | |
| SCHEMBL27413208 | 0.98 | TERT (0.66) | TERTPTPN1PPARGPPARDPPARA | |
| SCHEMBL2671376 | 0.87 | CES2 (0.62) | PTPN1PPARGPPARDPPARAHSD17B10 | |
| SCHEMBL336156 | 0.87 | CES2 (0.62) | PTPN1PPARGPPARDPPARAHSD17B10 | |
| SCHEMBL1066379 | 0.87 | CES2 (0.62) | PTPN1PPARGPPARDPPARAHSD17B10 | |
| SCHEMBL1088139 | 0.87 | CES2 (0.62) | PTPN1PPARGPPARDPPARAHSD17B10 | |
| SCHEMBL1067552 | 0.87 | CES2 (0.62) | PTPN1PPARGPPARDPPARAHSD17B10 | |
| SCHEMBL9188955 | 0.87 | CES2 (0.62) | PTPN1PPARGPPARDPPARAHSD17B10 | |
| SCHEMBL10596165 | 0.87 | CES2 (0.62) | PTPN1PPARGPPARDPPARAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691959-B2 | Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds | AVEXXIN AS (NO) | 2023-07-04 | — | — | US | disclosed |
| US-20220363659-A1 | ANTI-INFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS | AVEXXIN AS (NO) | 2022-11-17 | — | — | US | disclosed |
| CN-107074840-B | 2-oxothiazole compounds having activity as cPLA2 inhibitors for the treatment of inflammatory and hyperproliferative diseases | 埃维克辛公司 | 2022-04-26 | — | — | CN | disclosed |
| US-11034666-B2 | Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds | AVEXXIN AS (NO) | 2021-06-15 | — | — | US | disclosed |
| US-20210101913-A1 | 2-OXOTHIATOLE COMPOUNDS HAVING ACTIVITY AS CPLA2 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISORDERS AND HYPERPROLIFERATIVE DISORDERS | AVEXXIN AS (NO) | 2021-04-08 | — | — | US | disclosed |
| US-10851114-B2 | 2-oxothiatole compounds having activity as cPLA2 inhibitors for the treatment of inflammatory disorders and hyperproliferative disorders | AVEXXIN AS (NO) | 2020-12-01 | — | — | US | disclosed |
| US-20200299256-A1 | ANTI-INFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS | AVEXXIN AS (NO) | 2020-09-24 | — | — | US | disclosed |
| EP-3174873-B1 | 2-OXOTHIATOLE COMPOUNDS HAVING ACTIVITY AS CPLA2 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISORDERS AND HYPERPROLIFERATIVE DISORDERS | AVEXXIN AS (NO) | 2020-04-15 | — | — | EP | disclosed |
| US-20190345168-A1 | 2-OXOTHIATOLE COMPOUNDS HAVING ACTIVITY AS CPLA2 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISORDERS AND HYPERPROLIFERATIVE DISORDERS | AVEXXIN AS (NO) | 2019-11-14 | — | — | US | disclosed |
| CN-110128370-A | Anti-inflammatory and antitumor 2- oxothiazoiium class and 2- oxo thiophenes | 埃维克辛公司 | 2019-08-16 | — | — | CN | disclosed |
| EP-2951164-A1 | ANTIINFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS | Avexxin AS (NO) | 2015-12-09 | — | — | EP | disclosed |
| CN-105102438-A | Anti-inflammatory and anti-tumor 2-oxothiazoles and 2-oxothiophenes | AVEXXIN AS | 2015-11-25 | — | — | CN | disclosed |
| CN-104892542-A | ANTI INFLAMMATORY 2-OXOTHIAZOLES AND 2 -OXOOXAZOLES | AVEXXIN AS | 2015-09-09 | — | — | CN | disclosed |
| CN-102647984-B | Anti-inflammatory 2-carbonylthiazoles and 2-carbonyloxazoles | AVEXXIN AS | 2015-03-25 | — | — | CN | disclosed |
| WO-2014118195-A1 | ANTIINFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS | AVEXXIN AS (NO) | 2014-08-07 | — | — | WO | disclosed |
| CN-103772312-A | ANTI INFLAMMATORY 2-OXOTHIAZOLES AND 2 -OXOOXAZOLES | AVEXXIN AS | 2014-05-07 | — | — | CN | disclosed |
| CN-102647984-A | Anti-inflammatory 2-carbonylthiazoles and 2-carbonyloxazoles | AVEXXIN AS | 2012-08-22 | — | — | CN | disclosed |
| EP-2482815-A1 | ANTI INFLAMMATORY 2-OXOTHIAZOLES AND 2 -OXOOXAZOLES | Avexxin AS (NO) | 2012-08-08 | — | — | EP | disclosed |
| US-20110136879-A1 | COMPOUND | AVEXXIN AS (NO) | 2011-06-09 | — | — | US | disclosed |
| WO-2011039365-A1 | ANTI INFLAMMATORY 2-OXOTHIAZOLES AND 2 -OXOOXAZOLES | AVEXXIN AS (NO) | 2011-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136879-A1 | COMPOUND | CBR1, CBR3, CCR1 | TERT 3899/4885PTPN1 641/4885PPARG 1629/4885 |
| US-20210101913-A1 | 2-OXOTHIATOLE COMPOUNDS HAVING ACTIVITY AS CPLA2 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISORDERS AND HYPERPROLIFERATIVE DISORDERS | CYSLTR2, PLA2G4B, PLA2G4C | TERT 3073/4885PTPN1 1755/4885PPARG 1342/4885 |
| US-11034666-B2 | Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds | CASP1, OXER1, IL1B | TERT 1329/4885PTPN1 2189/4885PPARG 2215/4885 |
| US-10851114-B2 | 2-oxothiatole compounds having activity as cPLA2 inhibitors for the treatment of inflammatory disorders and hyperproliferative disorders | PLA2G4B, CYSLTR2, PLA2R1 | TERT 3014/4885PTPN1 1642/4885PPARG 1302/4885 |
| US-20200299256-A1 | ANTI-INFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS | CASP1, OXER1, IL1B | TERT 1271/4885PTPN1 2160/4885PPARG 2220/4885 |
| US-20220363659-A1 | ANTI-INFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS | OXER1, CASP1, IL6 | TERT 1171/4885PTPN1 2089/4885PPARG 2269/4885 |
| US-11691959-B2 | Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds | CASP1, IL1B, OXER1 | TERT 1435/4885PTPN1 2029/4885PPARG 2359/4885 |
| US-20190345168-A1 | 2-OXOTHIATOLE COMPOUNDS HAVING ACTIVITY AS CPLA2 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISORDERS AND HYPERPROLIFERATIVE DISORDERS | CYSLTR2, PLA2G4B, PLA2R1 | TERT 3023/4885PTPN1 1560/4885PPARG 1223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.