Sugi Predict

Sugi Predict / Compounds / SCHEMBL1670193

SCHEMBL1670193

SCHEMBL1670193

O=[N+]([O-])c1ccc(F)cc1S(=O)(=O)Cl

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ATM Q13315 1/20 0.61
▸ TDP1 Q9NUW8 1/20 0.61
▸ VCAM1 P19320 2/20 0.47
▸ HSPB1 P04792 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ LMNA P02545 2/20 0.42
▸ ALDH1A1 P00352 3/20 0.42
▸ HIF1A Q16665 1/20 0.42
▸ GAA P10253 2/20 0.40
▸ TSHR P16473 1/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ PDE7A Q13946 1/20 0.39
▸ TTR P02766 1/20 0.39
▸ CA1 P00915 2/20 0.38
▸ CA2 P00918 2/20 0.38
▸ MMP1 P03956 2/20 0.38
▸ MMP2 P08253 2/20 0.38
▸ MMP9 P14780 2/20 0.38
▸ MMP8 P22894 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3819613 0.86 ATM (0.52) ATMTDP1VCAM1HSPB1KMT2A
SCHEMBL1668045 0.82 ATM (0.61) ATMTDP1VCAM1HSPB1KMT2A
SCHEMBL11973894 0.82 TDP1 (0.61) ATMTDP1VCAM1HSPB1KMT2A
SCHEMBL20150270 0.82 ATM (0.61) ATMTDP1VCAM1HSPB1KMT2A
SCHEMBL11973607 0.81 VCAM1 (0.46) ATMTDP1VCAM1KMT2AMEN1
SCHEMBL23668294 0.80 ALDH1A1 (0.52) TDP1KMT2AMEN1LMNAALDH1A1
SCHEMBL31294301 0.80 ALDH1A1 (0.52) TDP1KMT2AMEN1LMNAALDH1A1
SCHEMBL2062571 0.80 MAPK1 (0.58) VCAM1KMT2AMEN1LMNAALDH1A1
SCHEMBL1668292 0.79 ATM (0.58) ATMTDP1VCAM1HSPB1KMT2A
SCHEMBL139871 0.79 TSHR (0.58) VCAM1KMT2AMEN1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240376092-A1 MODULATORS OF PrPC AND USES THEREOF FONDAZIONE TELETHON ETS (IT) 2024-11-14 — — US disclosed
WO-2024206347-A1 FUSED THIADIAZINE DIOXIDE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS, INC. (US) 2024-10-03 — — WO disclosed
WO-2024175450-A1 SUBSTITUTED S-ALANINATE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2024-08-29 — — WO disclosed
EP-4340844-A1 MODULATORS OF PRPC AND USES THEREOF Fondazione Telethon ETS (IT) 2024-03-27 — — EP disclosed
WO-2022243549-A1 MODULATORS OF PrPC AND USES THEREOF FONDAZIONE TELETHON (IT) 2022-11-24 — — WO disclosed
CN-108698982-B Fluorine atom-containing compound and use thereof 日产化学工业株式会社 2021-07-16 — — CN disclosed
EP-3404017-B1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF NISSAN CHEMICAL IND LTD (JP) 2020-05-13 — — EP disclosed
US-10336686-B2 Fluorine atom-containing compound and use thereof NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-07-02 — — US disclosed
US-20190031600-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-01-31 — — US disclosed
EP-3404017-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF Nissan Chemical Industries, Ltd. (JP) 2018-11-21 — — EP disclosed
EP-2488520-B1 CONDENSED AZINE-DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR MERCK SHARP & DOHME (NL) 2015-09-02 — — EP disclosed
US-9102688-B2 Sulfonaminoquinoline hepcidin antagonists VIFOR (INTERNATIONAL) AG (CH) 2015-08-11 — — US disclosed
US-20140364424-A1 Novel Sulfonaminoquinoline Hepcidin Antagonists VIFOR (INTERNATIONAL) AG (CH) 2014-12-11 — — US disclosed
US-8841289-B2 Heterocyclic derivatives MERCK SHARP & DOHME B.V. (US) 2014-09-23 — — US disclosed
EP-2675526-A1 NOVEL SULFONAMINOQUINOLINE HEPCIDIN ANTAGONISTS Vifor (International) AG (CH) 2013-12-25 — — EP disclosed
WO-2012110603-A1 NOVEL SULFONAMINOQUINOLINE HEPCIDIN ANTAGONISTS VIFOR (INTERNATIONAL) AG (CH) 2012-08-23 — — WO disclosed
US-20120214803-A1 Novel Sulfonaminoquinoline Hepcidin Antagonists VIFOR (INTERNATIONAL) AG (CH) 2012-08-23 — — US disclosed
EP-2488520-A1 CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR MSD Oss B.V. (NL) 2012-08-22 — — EP disclosed
US-20120208796-A1 HETEROCYCLIC DERIVATIVES ORGANON BIOSCIENCES NEDERLAND B.V. (NL) 2012-08-16 — — US disclosed
WO-2011045258-A1 CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR N.V. ORGANON (NL) 2011-04-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10336686-B2 Fluorine atom-containing compound and use thereof ARF1, ARF5, ARFGAP1 ATM 2579/4885TDP1 4470/4885VCAM1 3977/4885
US-20120214803-A1 Novel Sulfonaminoquinoline Hepcidin Antagonists HAMP, SLC40A1, FTH1 ATM 4568/4885TDP1 4862/4885VCAM1 3058/4885
US-20240376092-A1 MODULATORS OF PrPC AND USES THEREOF PRNP, PRPH, PRP4K ATM 3975/4885TDP1 377/4885VCAM1 1905/4885
US-20120208796-A1 HETEROCYCLIC DERIVATIVES CHRNA5, CHRM5, CHRNA7 ATM 3990/4885TDP1 2173/4885VCAM1 1958/4885
US-20190031600-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF ARF1, ARF5, ARFGAP1 ATM 2579/4885TDP1 4470/4885VCAM1 3977/4885
US-20140364424-A1 Novel Sulfonaminoquinoline Hepcidin Antagonists HAMP, SLC40A1, FTH1 ATM 4568/4885TDP1 4862/4885VCAM1 3058/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.