Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 6/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | BRD2 | P25440 | 2/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12800445 | 0.82 | PTGS2 (0.42) | PTGS2NTRK1PIM1BRD4BRD2 | |
| SCHEMBL1672841 | 0.78 | MAOA (0.39) | PTGS2NTRK1PIM1BRD4THRB | |
| SCHEMBL12986874 | 0.78 | CREBBP (0.39) | PTGS2BRD4MAPTCREBBPMAPK1 | |
| SCHEMBL1670583 | 0.77 | MAOA (0.38) | PTGS2NTRK1PIM1BRD4MAPT | |
| SCHEMBL1672794 | 0.73 | PTGS2 (0.44) | PTGS2BRD4BRD2BRD3MAPT | |
| SCHEMBL1670708 | 0.68 | PTGS2 (0.43) | PTGS2BRD4MAPTSMN1; SMN2KDM4E | |
| SCHEMBL1670709 | 0.67 | PTGS2 (0.48) | PTGS2BRD4BRD2BRD3CREBBP | |
| SCHEMBL12800447 | 0.67 | PTGS2 (0.41) | PTGS2BRD4BRD2BRD3MAPT | |
| SCHEMBL13195254 | 0.67 | PTGS2 (0.41) | PTGS2BRD4MAPT | |
| SCHEMBL1670920 | 0.67 | PTGS2 (0.47) | PTGS2BRD4BRD2BRD3CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |