Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1672841 | 0.88 | MAOA (0.39) | MAOAPTGS2NPC1RAB9ABRD4 | |
| SCHEMBL1670731 | 0.86 | BRD4 (0.34) | BRD4 | |
| SCHEMBL12800962 | 0.83 | PTGS2 (0.40) | PTGS2NPC1RAB9ABRD4MAPT | |
| SCHEMBL12986874 | 0.81 | CREBBP (0.39) | PTGS2RAB9ABRD4MAPTKDM4E | |
| SCHEMBL1670344 | 0.77 | PTGS2 (0.39) | MAOAPTGS2BRD4MAPTKDM4E | |
| SCHEMBL12800447 | 0.72 | PTGS2 (0.41) | PTGS2NPC1RAB9ABRD4MAPT | |
| SCHEMBL12800989 | 0.68 | BRD4 (0.35) | BRD4 | |
| SCHEMBL1670709 | 0.68 | PTGS2 (0.48) | PTGS2BRD4 | |
| SCHEMBL13195254 | 0.67 | PTGS2 (0.41) | PTGS2BRD4MAPTALDH1A1CYP3A4 | |
| SCHEMBL1670708 | 0.67 | PTGS2 (0.43) | PTGS2NPC1RAB9ABRD4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |