Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1670909 | 0.81 | PTGS2 (0.40) | PTGS2BRD4MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL12800447 | 0.75 | PTGS2 (0.41) | PTGS2BRD4MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1670212 | 0.74 | PTGS2 (0.44) | PTGS2BRD4MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1672841 | 0.72 | MAOA (0.39) | PTGS2BRD4MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL12800445 | 0.71 | PTGS2 (0.42) | PTGS2BRD4MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13195254 | 0.70 | PTGS2 (0.41) | PTGS2BRD4MAPTALDH1A1NPSR1 | |
| SCHEMBL12800962 | 0.69 | PTGS2 (0.40) | PTGS2BRD4MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL12987843 | 0.69 | TUBB4A (0.40) | PTGS2BRD4ALDH1A1 | |
| SCHEMBL1672794 | 0.68 | PTGS2 (0.44) | PTGS2BRD4MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1670344 | 0.68 | PTGS2 (0.39) | PTGS2BRD4MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |